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Arg tyrosine kinase is involved in homologous recombinational DNA repair
http://hdl.handle.net/2297/1650
http://hdl.handle.net/2297/1650b9207515-f799-4226-9a63-79a90117c6fb
名前 / ファイル | ライセンス | アクション |
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CA-PR-YAMAMOTO-K-Li et al(BBRC.pdf (107.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Arg tyrosine kinase is involved in homologous recombinational DNA repair | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Li, Yingzhu
× Li, Yingzhu× Shimizu, Hiroko× Xiang, Shuang-Lin× Maru, Yoshiro× Takao, Noriaki× Yamamoto, Ken-ichi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん研究所 | |||||
書誌情報 |
Biochemical and biophysical research communications 巻 299, 号 5, p. 697-702, 発行日 2002-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/s0006-291x(02)02692-x | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | c-Abl plays important roles in cellular response to DNA damage. However, possible roles for Arg (Abl-related gene) in DNA damage response are unknown. Here, we show that ionizing radiation (IR)-induced Rad51 focus formation is reduced in Arg-deficient cells generated from a chicken B cell line by targeted disruption. This is consistent with the findings that Arg-deficient cells display hypersensitivity to IR, elevated frequencies of IR-induced chromosomal aberrations, and reduced targeted integration frequencies. All of these abnormalities in DNA damage repair are also observed in ATM-deficient cells but not in c-Abl-deficient cells. Finally, we show that Arg interacts with and phosphorylates Rad51 in 293T cells. These results suggest that Arg plays a role in homologous recombinational (HR) DNA repair by phosphorylating Rad51. | |||||
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出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
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識別子タイプ | URI | |||||
関連識別子 | http://www.elsevier.com/locate/issn/0006291X |