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However, few studies have examined the effects of carvedilol on septic shock. The present study evaluated the effects of carvedilol pretreatment in cecal ligation and puncture (CLP)-induced septic shock in rats. \n Methods: Male Sprague Dawley rats (n = 90) were randomly assigned to one of the following three groups (n = 30 per group): control group (no medication), high-dose carvedilol group (10 mg/kg/day, orally administered for 5 days), and low-dose carvedilol group (2 mg/kg/day, orally administered for 5 days). Septic shock was induced by CLP, and the animals received no other therapies. Mortality was calculated for 5 days after CLP. Arterial blood gases and plasma cytokine concentrations were measured in 36 additional male rats 12 hr after CLP. \n Results: Mortality rates 5 days after CLP were 76.7%, 86.7%, and 86.7% in the control, high-dose, and low-dose groups, respectively; there were no significant differences among the three groups. 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Effects of carvedilol pretreatment on mortality and inflammatory responses to septic shock induced by cecal ligation and puncture in rats
https://doi.org/10.24517/00051111
https://doi.org/10.24517/000511117e1851ee-843d-4c23-bba1-fe953de4d3e1
名前 / ファイル | ライセンス | アクション |
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AN00044397-127-1-10-15.pdf (1.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-06-18 | |||||
タイトル | ||||||
タイトル | Effects of carvedilol pretreatment on mortality and inflammatory responses to septic shock induced by cecal ligation and puncture in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | beta-blocker | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | carvedilol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | sepsis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | shock | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cytokine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051111 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Yuki, Midori
× Yuki, Midori |
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書誌情報 |
金沢大学十全医学会雑誌 en : Journal of the Juzen Medical Society 巻 127, 号 1, p. 10-15, 発行日 2018-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-7226 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00044397 | |||||
出版者 | ||||||
出版者 | 金沢大学十全医学会 | |||||
出版者(別名) | ||||||
出版者 | The Juzen Medical Society Kanazawa University | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: Carvedilol, a nonselective beta-adrenoceptor and selective alpha 1-adrenoceptor blocker, has high efficacy and is widely used in hypertensive and/or cardiac failure patients. However, few studies have examined the effects of carvedilol on septic shock. The present study evaluated the effects of carvedilol pretreatment in cecal ligation and puncture (CLP)-induced septic shock in rats. Methods: Male Sprague Dawley rats (n = 90) were randomly assigned to one of the following three groups (n = 30 per group): control group (no medication), high-dose carvedilol group (10 mg/kg/day, orally administered for 5 days), and low-dose carvedilol group (2 mg/kg/day, orally administered for 5 days). Septic shock was induced by CLP, and the animals received no other therapies. Mortality was calculated for 5 days after CLP. Arterial blood gases and plasma cytokine concentrations were measured in 36 additional male rats 12 hr after CLP. Results: Mortality rates 5 days after CLP were 76.7%, 86.7%, and 86.7% in the control, high-dose, and low-dose groups, respectively; there were no significant differences among the three groups. Furthermore, observed decreases in base excess, increases in lactate concentrations, and increases in cytokine concentrations in the carvedilol-treated groups did not differ from those in the control group. Conclusions: The present findings indicate that orally administered carvedilol has no beneficial effects on mortality and inflammatory responses in CLP-induced septic shock in rats, suggesting that carvedilol may not contribute to recovery from septic shock. |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
見出し | ||||||
大見出し | 原著 | |||||
言語 | ja | |||||
見出し | ||||||
大見出し | Originals | |||||
言語 | en |