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荷重がラット後肢筋の廃用性萎縮予防に及ぼす効果 : 週内頻度からの検討
http://hdl.handle.net/2297/7330
http://hdl.handle.net/2297/7330a3f92f7e-5e52-4b02-a491-89decc63c8e0
名前 / ファイル | ライセンス | アクション |
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ME-PR-YAMAZAKI-T-108.pdf (995.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | 荷重がラット後肢筋の廃用性萎縮予防に及ぼす効果 : 週内頻度からの検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of Weight-Bearing in Prevention of Disuse Atrophy in Rat Hindlimb Muscles : Study of Weight-Bearing Frequency in a Week | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
山崎, 俊明
× 山崎, 俊明× 灰田, 信英× 立野, 勝彦 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学大学院医学系研究科活動能力回復学 | |||||
書誌情報 |
理学療法学 巻 22, 号 3, p. 108-113, 発行日 1995-05-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0289-3770 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11545224 | |||||
出版者 | ||||||
出版者 | 日本理学療法士協会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 荷重が廃用性筋萎縮の進行抑制に及ぼす効果を, 週内頻度(隔日と毎日)の違いから検討した。24匹のラットを4群に分けた。実験群は(1)2週間の寡運動(非荷重)中に荷重しない群, (2)寡運動中に1時間荷重を隔日に加えた群, (3)寡運動中に1時間荷重を毎日実施した群とし, 1群を対照群とした。その後, ヒラメ筋と長指伸筋を摘出し重量を測定した。さらにATP染色により筋線維タイプを分類(I・II)し, 断面積を測定した。その結果, (1)非荷重および荷重による影響は, 長指伸筋よりヒラメ筋で著明であった。(2)ヒラメ筋の相対重量比およびタイプ構成比率は, 毎日1時間荷重することで維持可能であった。(3)ヒラメ筋断面積は, 荷重しないより隔日, 隔日より毎日荷重の方が有意に大きかった。以上より, 一日1時間の荷重は, 廃用性筋萎縮の進行抑制が可能であり, 隔日荷重より毎日荷重の方が効果的なことが示唆された。 The purpose of this study was to investigate the effect of weight-bearing frequency in a week in prevention of disuse muscular atrophy. Hindlimb suspension (HS) was used to produce muscular atrophy in Wistar rats (n=24). Weight-bearing (WB) was stationary ground support (1 hour/day). Groups were 1) HS only, 2) HS+WB (every other day), 3) HS+WB (everyday), and 4) control. After 2 weeks, right soleus muscle (SOL) and extensor digitorum longus muscle (EDL) were weighed. Muscle ATPase histochemical staining, followed by morphometrical analysis, demonstrated that SOL responded more markedly to non-WB and WB than EDL. The muscle-to-body weight ratio and the percentage distribution of muscle fiber type in SOL were maintained by everyday WB. Muscular atrophy could not be prevented perfectly. But cross-sectional area in SOL indicated that it is possible to delay the progression of disuse muscular atrophy by WB (1 hour/day), and that everyday WB is more effective compared with every other day WB. | |||||
権利 | ||||||
権利情報 | 本文データは日本理学療法士協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://ci.nii.ac.jp/naid/110004007937/ |