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Is Estrogen Effective for Full-Thickness Cutaneous Wound Healing in Young Male Mice ?
http://hdl.handle.net/2297/35866
http://hdl.handle.net/2297/3586627a4cc6e-9056-472f-83c7-3968cb147cb5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-NAKATANI-T-278.pdf (585.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Is Estrogen Effective for Full-Thickness Cutaneous Wound Healing in Young Male Mice ? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Nakajima, Yukari
× Nakajima, Yukari× Eno, Yuka× Hirata, Mariko× Kobori, Sawako× Sugiura, Ayano× Takeuchi, Maiko× Taniguchi, Miho× Tanisaki, Megumi× Hayashi, Asuka× Hikishima, Keiko× Matsuo, Naoki× Wada, Natsumi× Mukai, Kanae× Murakado, Naoko× Okuwa, Mayumi× Nakatani, Toshio |
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| 書誌情報 |
Wounds : a compendium of clinical research and practice 巻 25, 号 10, p. 278-286, 発行日 2013-10-15 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1044-7946 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11196613 | |||||
| 出版者 | ||||||
| 出版者 | Health Management Publications | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this study is to show the effects of estrogen upon its topical application on the wound healing process in young male mice. Fifty-six male mice aged 7 weeks old were divided into 4 groups: sham operation, castration, estrogen treatment after sham operation, and estrogen treatment after castration. Wound healing was observed daily until day 14 after wounding. Specimens were harvested on days 3, 7, 10, and 14, and stained to evaluate reepithelialization, inflammation, contraction, and collagen accumulation. Wound healing periods of all groups were almost the same, although the concentration of serum estrogen in the estrogen-applied mice was very high, and that in the nonapplied groups was low. The numbers of macrophages in the castrated, estrogen-treated after sham operation, and estrogen-treated after castration groups were significantly decreased compared with that in the sham group in the inflammatory phase; however, the ratio of wound area in these groups did not decrease, and other histological data did not reveal any effects of estrogen. These results indicate that estrogen may show limited effectiveness for full-thickness cutaneous wound healing in young male mice, and decreased inflammation may not always be associated with decreased wound area. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.woundsresearch.com | |||||
