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  1. C. 医薬保健学域; 医学類・薬学類・医薬科学類・保健学類
  2. c 10. 学術雑誌掲載論文(医・保健)
  3. 1. 査読済論文(医学・保健)

Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts

https://doi.org/10.24517/00013643
https://doi.org/10.24517/00013643
9e6c514f-d7d5-43df-82f1-b1abbe11d168
名前 / ファイル ライセンス アクション
ME-PR-MUNESUE-S-1835.pdf ME-PR-MUNESUE-S-1835.pdf (347.5 kB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-10-03
タイトル
タイトル Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
ID登録
ID登録 10.24517/00013643
ID登録タイプ JaLC
著者 Munesue, Seiichi

× Munesue, Seiichi

WEKO 21843
e-Rad 10399040
金沢大学研究者情報 10399040
研究者番号 10399040

Munesue, Seiichi

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Yamamoto, Yasuhiko

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WEKO 100
e-Rad 20313637
金沢大学研究者情報 20313637
研究者番号 20313637

Yamamoto, Yasuhiko

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Urushihara, Ryouta

× Urushihara, Ryouta

WEKO 22803

Urushihara, Ryouta

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Inomata, Kouhei

× Inomata, Kouhei

WEKO 22804

Inomata, Kouhei

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Takatsuji-Saito, Hidehito

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WEKO 22805
e-Rad 40768959

Takatsuji-Saito, Hidehito

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Motoyoshi, So

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WEKO 22806

Motoyoshi, So

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Watanabe, Takuo

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WEKO 193
e-Rad 40303268
研究者番号 40303268

Watanabe, Takuo

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Yonekura, Hideto

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WEKO 20132
e-Rad 80240373
研究者番号 80240373

Yonekura, Hideto

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Yamamoto, Hiroshi

× Yamamoto, Hiroshi

WEKO 52
e-Rad 00115198
研究者番号 00115198

Yamamoto, Hiroshi

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著者別表示 棟居, 聖一

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棟居, 聖一

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山本, 靖彦

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山本, 靖彦

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高辻-齋藤, 英仁

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高辻-齋藤, 英仁

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渡邉, 琢夫

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渡邉, 琢夫

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米倉, 秀人

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米倉, 秀人

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山本, 博

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山本, 博

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書誌情報 Food and Function

巻 4, 号 12, p. 1835-1842, 発行日 2013-12-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 2042-6496
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1039/c2fo30359k
出版者
出版者 Royal Society of Chemistry
抄録
内容記述タイプ Abstract
内容記述 Advanced glycation end-products (AGE) have been implicated in aging and the pathogenesis of diabetic complications, inflammation, Alzheimer's disease, and cancer. AGE engage the cell surface receptor for AGE (RAGE), which in turn elicits intracellular signaling, leading to activation of NF-κB to cause deterioration of tissue homeostasis. AGE are not only formed within our bodies but are also derived from foods, endowing them with flavor. In the present study, we assessed the agonistic/antagonistic effects of food-derived AGE on RAGE signaling in a reporter assay system and found that low-molecular weight AGE can antagonize the action of AGE-BSA. Foods tested were Japanese soy sauce, coffee, cola, and red wine, all of which showed fluorescence characteristics of AGE. Soy sauce and coffee contained Nε-carboxymethyl-lysine (CML). Soy sauce, coffee, and red wine inhibited the RAGE ligand-induced activation of NF-κB, whereas cola had no effect on the ligand induction of NF-κB. The liquids were then fractionated into high-molecular weight (HMW) fractions and low-molecular weight (LMW) fractions. Soy sauce-, coffee-, and red wine-derived LMW fractions consistently inhibited the RAGE ligand induction of NF-κB, whereas the HMW fractions of these foods activated RAGE signaling. Using the LMW fraction of soy sauce as a model food-derived RAGE antagonist, we performed a plate-binding assay and found that the soy sauce LMW fractions competitively inhibited AGE-RAGE association. Further, this fraction significantly reduced AGE-dependent monocyte chemoattractant protein-1 (MCP-1) secretion from murine peritoneal macrophages. The LMF from soy sauce suppressed the AGE-induced RAGE trafficking to lipid rafts. These results indicate that small components in some, if not all, foods antagonize RAGE signaling and could exhibit beneficial effects on RAGE-related diseases. © 2013 The Royal Society of Chemistry.
著者版フラグ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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