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Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome
http://hdl.handle.net/2297/30298
http://hdl.handle.net/2297/30298eb86676e-fea4-43b9-97d4-f397357d08ab
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-FUJIMURA-M-7.pdf (214.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ishiura, Yoshihisa
× Ishiura, Yoshihisa× Fujimura, Masaki× Yamamoto, Hiroki× Ohkura, Noriyuki× Myou, Shigeharu |
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| 書誌情報 |
Cough 巻 6, 号 11, p. 7, 発行日 2011-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1745-9974 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/1471-213X-10-84 | |||||
| 出版者 | ||||||
| 出版者 | BioMed Central | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase (COX)-2, one of the inducible isoforms of COX, is a key element in the pathophysiological process of a number of inflammatory disorders. However, little is known about the role of COX-2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation.Methods: The effect of etodolac, a potent COX-2 inhibitor, on cough response to inhaled capsaicin was examined in 15 patients with sinobronchial syndrome in a randomized, placebo-controlled cross-over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity.Results: The cough threshold was significantly (p < 0.03) increased after two-week treatment with etodolac (200 mg twice a day orally) compared with placebo [37.5 (GSEM 1.3) vs. 27.2 (GSEM 1.3) μM].Conclusions: These findings indicate that COX-2 may be a possible modulator augmenting airway cough reflex sensitivity in patients with sinobronchial syndrome. © 2010 Ishiura et al; licensee BioMed Central Ltd. | |||||
| 権利 | ||||||
| 権利情報 | © 2010 Ishiura et al; licensee BioMed Central Ltd. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.coughjournal.com/content/6/1/7 | |||||
