{"_buckets": {"deposit": "86219384-679f-4251-b679-75820158c42c"}, "_deposit": {"created_by": 3, "id": "13791", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "13791"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00013791", "sets": ["1134"]}, "author_link": ["23192", "23190", "21777", "594", "23189", "62", "567", "736", "23191"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-03-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "294", "bibliographicPageStart": "287", "bibliographicVolumeNumber": "35", "bibliographic_titles": [{"bibliographic_title": "Hypertension Research"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Aldosterone is implicated in the pathogenesis of several cardiovascular diseases, including ischemia reperfusion (I/R) and myocardial infarction, and also causes oxidative stress and inflammation in cardiovascular systems. Benidipine, a long-acting T-and L-type calcium channel blocker, reduces infarct size following myocardial I/R in rabbits. Benidipine also inhibits the production of aldosterone in vitro. However, the precise mechanism of this phenomenon in vivo remains unknown. We therefore evaluated whether benedipine has a beneficial role through the regulation of oxidative stress in myocardial I/R. C57BL/6J mice were subjected to 30 min of left ascending coronary I/R. Benidipine was administered orally at 3 mg kg -1daily for 3 weeks without any changes in hemodynamic variables. Benidipine significantly reduced infarction size (13.4±2.5%) compared with controls (25.5±3.6%). Urinary 8-hydroxy-2′ deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, increased significantly after I/R. I/R induced increases in 8-OHdG were significantly lower with benidipine. Local myocardial 8-OHdG was also elevated in I/R, but this augmentation was significantly suppressed with benidipine. The plasma aldosterone concentration (PAC) significantly increased 2 days after I/R and remained elevated at least 7 days after I/R. Treatment with benidipine significantly decreased I/R-induced elevation of the PAC. I/R-induced markers of fibrosis in hearts also reduced in benidipine. These results suggest that the administration of benidipine reduces myocardial infarct size as well as systemic oxidative stress after I/R. These phenomena are partially linked to reduced plasma aldosterone levels. © 2012 The Japanese Society of Hypertension All rights reserved.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Japanese Society of Hypertension 日本高血圧学会 / Nature Publishing Group"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/hr.2011.183", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.jpnsh.org/", "subitem_relation_type_select": "URI"}}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10847079", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": 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{"creatorNames": [{"creatorName": "Kaneko, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "62", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60185923", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60185923"}, {"nameIdentifier": "60185923", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60185923"}, {"nameIdentifier": "60185923", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060185923"}]}, {"creatorNames": [{"creatorName": "Takashima, Shin-ichiro"}], "nameIdentifiers": [{"nameIdentifier": "23190", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitano, Katsunori"}], "nameIdentifiers": [{"nameIdentifier": "23191", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Kanako"}], "nameIdentifiers": [{"nameIdentifier": "23192", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": 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"attribute_value_mlt": [{"subitem_subject": "aldosterone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "calcium channel blocker", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ischemia reperfusion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oxidative stress", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice"}]}, "item_type_id": "4", "owner": "3", "path": ["1134"], "permalink_uri": "http://hdl.handle.net/2297/32000", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-03"}, "publish_date": "2017-10-03", "publish_status": "0", "recid": "13791", "relation": {}, "relation_version_is_last": true, "title": ["Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice"], "weko_shared_id": -1}