| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-03 |
| タイトル |
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|
タイトル |
Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00014071 |
|
ID登録タイプ |
JaLC |
| 著者 |
Kawaguchi, Kazunori
Honda, Masao
Yamashita, Taro
Okada, Hikari
Shirasaki, Takayoshi
Nishikawa, Masashi
Nio, Kouki
Arai, Kuniaki
Sakai, Yoshio
Yamashita, Tatsuya
Mizukoshi, Eishiro
Kaneko, Shuichi
|
| 著者別表示 |
本多, 政夫
山下, 太郎
白崎, 尚芳
西川, 昌志
丹尾, 幸樹
荒井, 邦明
酒井, 佳夫
山下, 竜也
水腰, 英四郎
金子, 周一
|
| 提供者所属 |
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|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学先進予防医学研究センター / 金沢大学医薬保健研究域医学系 |
| 書誌情報 |
American Journal of Pathology
巻 186,
号 8,
p. 2055-2067,
発行日 2016-08-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0002-9440 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00520990 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.ajpath.2016.04.011 |
| 出版者 |
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出版者 |
Elsevier |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Notch signaling abnormalities are reported to be involved in the acceleration of malignancy in solid tumors and stem cell formation or regeneration in various organs. We analyzed specific genes for DNA copy number variations in liver cancer cells and investigated whether these factors relate to clinical outcome. Chromosome 20p, which includes the ligand for Notch pathways, Jagged1, was found to be amplified in several types of hepatoma cells, and its mRNA was up-regulated according to α-fetoprotein gene expression levels. Notch inhibition using Jagged1 shRNA and γ-secretase inhibitors produced significant suppression of cell growth in α-fetoprotein–producing cells with suppression of downstream genes. Using in vivo hepatoma models, the administration of γ-secretase inhibitors resulted in reduced tumor sizes and effective Notch inhibition with widespread apoptosis and necrosis of viable tumor cells. The γ-secretase inhibitors suppressed cell growth of the epithelial cell adhesion molecule–positive fraction in hepatoma cells, indicating that Notch inhibitors could suppress the stem cell features of liver cancer cells. Even in clinical liver cancer samples, the expression of α-fetoprotein and Jagged1 showed significant correlation, and amplification of the copy number of Jagged1 was associated with Jagged1 mRNA expression and poor survival after liver cancer surgical resection. In conclusion, amplification of Jagged1 contributed to mRNA expression that activates the Jagged1-Notch signaling pathway in liver cancer and led to poor outcome. © 2016 American Society for Investigative Pathology |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
Embargo Period 12 months |
| 権利 |
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|
権利情報 |
Copyright ©Elsevier(CC-BY NC ND) |
| 著者版フラグ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
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|
識別子タイプ |
URI |
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|
関連識別子 |
http://www.elsevier.com/locate/issn/00029440 |
ME-PR-KANEKO-S-2055.pdf (375.8 kB)
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