WEKO3
インデックスリンク
アイテム
Protein kinase A and Epac activation by cAMP regulateS the expression of glial fibrillary acidic protein in glial cells
http://hdl.handle.net/2297/46779
http://hdl.handle.net/2297/4677967507eea-64f7-47cd-a96e-a23043eec8b2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-SUGIMOTO-N-795.pdf (1.1 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Protein kinase A and Epac activation by cAMP regulateS the expression of glial fibrillary acidic protein in glial cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sugimoto, Naotoshi
× Sugimoto, Naotoshi× Miwa, Shinji× Nakamura, Hiroyuki× Tsuchiya, Hiroyuki× Yachie, Akihiro |
|||||
| 書誌情報 |
Archives of Biological Sciences 巻 68, 号 4, p. 795-801, 発行日 2016-01-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0354-4664 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00547181 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2298/ABS160112067S | |||||
| 出版者 | ||||||
| 出版者 | Serbian Biological Society / Institut za Bioloska Istrazivanja | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cyclic adenosine monophosphate (cAMP) controls differentiation in several types of cells during brain development. However, the molecular mechanism of cAMP-controlled differentiation is not fully understood. We investigated the role of protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac) on cAMP-induced glial fibrillary acidic protein (GFAP), an astrocyte marker, in cultured glial cells. B92 glial cells were treated with cAMP-elevating drugs, an activator of adenylate cyclase, phosphodiesterase inhibitor and a β adrenal receptor agonist. These cAMP-elevating agents induced dramatic morphological changes and expression of GFAP. A cAMP analog, 8-Br-cAMP, which activates Epac as well as PKA, induced GFAP expression and morphological changes, while another cAMP analog, 8-CPT-cAMP, which activates Epac with greater efficacy when compared to PKA, induced GFAP expression but very weak morphological changes. Most importantly, the treatment with a PKA inhibitor partially reduced cAMP-induced GFAP expression. Taken together, these results indicate that cAMP-elevating drugs lead to the induction of GFAP via PKA and/or Epac activation in B92 glial cells. © 2016 by the Serbian Biological Society. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
