| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-05-10 |
| タイトル |
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タイトル |
Long-term histopathological developments in knee-joint components in a rat model of osteoarthritis induced by monosodium iodoacetate |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00014185 |
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ID登録タイプ |
JaLC |
| 著者 |
Takahashi, Ikufumi
Matsuzaki, Taro
Hoso, Masahiro
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| 著者別表示 |
髙橋 , 郁文
松﨑, 太郎
細, 正博
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| 書誌情報 |
Journal of Physical Therapy Science
巻 29,
号 4,
p. 590-597,
発行日 2017-01-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0915-5287 |
| NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10798949 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1589/jpts.29.590 |
| 出版者 |
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出版者 |
Society of Physical Therapy Science = 理学療法科学学会 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
[Purpose] This study was performed to evaluate the long-term histopathological changes in knee-joint components including synovial membrane and joint capsule in a rat model of osteoarthritis (OA) induced by monosodium iodoacetate (MIA). [Subjects and Methods] Fifty male rats were used. OA was induced through intra-articular injection of MIA, and ten rats were randomly allocated to each of five groups induced with OA for 1, 2, 4, 6, or 8 weeks. At the end of each period, the knee components were examined histopathologically. [Results] After 1 and 2 weeks, chondrocytes were weakly stained. After 4 weeks, fibrillation, fissuring, and eburnation were observed, whereas after 6 weeks, chondrocyte clustering and osteophyte formation were detected. In the synovial membrane, the proliferation of spindle-shaped cells and a multilayered structure of the surface cells were observed at 1 and 2 weeks, but the degree of these changes decreased over time. In the joint capsule, a narrowing of the space between collagen fiber bundles was observed at 4–8 weeks. [Conclusion] The long-term histopathological changes of the joint components observed in a rat model of OA induced by MIA were similar to those detected in OA, but differed at specific times and tissues. |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
出版者照会後に全文公開 |
| 権利 |
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|
権利情報 |
Copyright © 2017 by the Society of Physical Therapy Science. Published by IPEC Inc. 理学療法科学学会 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jstage.jst.go.jp/browse/jpts |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://spts.jpn.com/en/ |
ME-PR-TAKAHASHI-I-590.pdf (1.9 MB)
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