WEKO3
インデックスリンク
アイテム
Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient.
http://hdl.handle.net/2297/48359
http://hdl.handle.net/2297/48359d06bd541-2bd3-402a-97b3-1f994bcad978
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-YAMAGISHI-M-44312.pdf (2.5 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Shimojima, Masaya
× Shimojima, Masaya× Yuasa, Shinsuke× Motoda, Chikaaki× Yozu, Gakuto× Nagai, Toshihiro× Ito, Shogo× Lachmann, Mark× Kashimura, Shin× Takei, Makoto× Kusumoto, Dai× Kunitomi, Akira× Hayashiji, Nozomi× Seki, Tomohisa× Tohyama, Shugo× Hashimoto, Hisayuki× Kodaira, Masaki× Egashira, Toru× Hayashi, Kenshi× Nakanishi, Chiaki× Sakata, Kenji× Yamagishi, Masakazu× Fukuda, Keiichi |
|||||
| 書誌情報 |
Scientific Reports 巻 7, p. 44312, 発行日 2017-03-14 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/srep44312 | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Alteration of the nuclear Ca2+ transient is an early event in cardiac remodeling. Regulation of the nuclear Ca2+ transient is partly independent of the cytosolic Ca2+ transient in cardiomyocytes. One nuclear membrane protein, emerin, is encoded by EMD, and an EMD mutation causes Emery-Dreifuss muscular dystrophy (EDMD). It remains unclear whether emerin is involved in nuclear Ca2+ homeostasis. The aim of this study is to elucidate the role of emerin in rat cardiomyocytes by means of hypertrophic stimuli and in EDMD induced pluripotent stem (iPS) cell-derived cardiomyocytes in terms of nuclear structure and the Ca2+ transient. The cardiac hypertrophic stimuli increased the nuclear area, decreased nuclear invagination, and increased the half-decay time of the nuclear Ca2+ transient in cardiomyocytes. Emd knockdown cardiomyocytes showed similar properties after hypertrophic stimuli. The EDMD-iPS cell-derived cardiomyocytes showed increased nuclear area, decreased nuclear invagination, and increased half-decay time of the nuclear Ca2+ transient. An autopsied heart from a patient with EDMD also showed increased nuclear area and decreased nuclear invagination. These data suggest that Emerin plays a crucial role in nuclear structure and in the nuclear Ca2+ transient. Thus, emerin and the nuclear Ca2+ transient are possible therapeutic targets in heart failure and EDMD. © The Author(s) 2017. | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2017. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
