{"_buckets": {"deposit": "079a303b-511a-4771-b90f-eef03a616438"}, "_deposit": {"created_by": 3, "id": "14527", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "14527"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00014527", "sets": ["1134"]}, "author_link": ["25541", "25540", "603", "20083", "1442", "20086"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-01-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "36", "bibliographicPageStart": "33", "bibliographicVolumeNumber": "4", "bibliographic_titles": [{"bibliographic_title": "日本補完代替医療学会誌 = Japanese journal of complementary and alternative medicine"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "【目的】喫煙と発癌との因果関係は数多く報告されている．今回，我々は喫煙による有害作用として，活性酸素による DNA 酸化修飾物質であり発癌との因果関係も指摘されている 8-ヒドロキシデオキシグアノシン (8-OHdG) を指標に抗酸化成分による介入試験を行った． 【対象と方法】健康な喫煙者（男性 6 名，女性 6 名，平均年齢 38 歳，平均 Brinkmann 指数 264）を対象に行った．抗酸化成分として PICACE® (Pycnogenol® 15 mg/capsule, Vitamin E; 56.1 mg/capsule, Squalene; 138.9 mg/capsule) 4 カプセル/日を 14 日間服用し，服用前，服用後 3，7，14 日目，服用終了後 1 ヶ月目の尿中 8-OHdG を高速液体クロマトグラフィー (HPLC) 法で測定した． 【結果】服用 3 日目の尿中 8-OHdG は，クレアチニン換算値で 3.7±1.3 ng/mg CRE（平均±標準偏差）で，服用前の 5.0±2.0 ng/mg CRE より有意に低下していた (p\u003c0.01)．服用終了後 1 ヶ月目の尿中 8-OHdG は，4.7±0.9 ng/mg CRE であり，投与中止によって再上昇した． 【結論】抗酸化成分複合物である PICACE® は，喫煙による DNA 酸化傷害を抑制することが示唆された． Oxidative stress is considered to contribute to degenerative disease. The urinary excretion of the DNA repair product 8-hydroxy-2′-deoxyguanosine (8-OHdG) is proposed as a noninvasive biomarker of current oxidative stress in vivo. We investigated the effect of an antioxidant mixture on urinary 8-OHdG excretions in 12 otherwise healthy smokers. During the intervention period for 2 weeks, subjects consumed four capsules of PICACE® (Pycnogenol® 15 mg/capsule, Vitamin E; 56.1 mg/capsule, Squalene; 138.9 mg/capsule) per day. On days 0 (pre-internal use), 3, 7, 14, and 44, morning urine samples were collected. The urinary 8-OHdG was measured using high-performance liquid chromatography (HPLC). The urinary 8-OHdG level on day 3 was significantly reduced compared to day 0. The level of 8-OHdG after a washout period for PICACE® (days 44) returned to day 0 baseline. These preliminary data suggest that PICACE® supplements can protect smokers from oxidative stress and possibly reduce disease risk caused by free radicals associated with smoking.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本補完代替医療学会 = The Japanese Society for Complementary and Alternative Medicine"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1625/jcam.4.33", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.jcam-net.jp/index.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ci.nii.ac.jp/naid/130000079390", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://japanlinkcenter.org/JST.JSTAGE/jcam/4.33", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) 2007 日本補完代替医療学会"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12095429", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1348-7922", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "大野, 智"}], "nameIdentifiers": [{"nameIdentifier": "20083", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90345629", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90345629"}, {"nameIdentifier": "90345629", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090345629"}]}, {"creatorNames": [{"creatorName": "大野, 由美子"}], "nameIdentifiers": [{"nameIdentifier": "25540", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木, 信孝"}], "nameIdentifiers": [{"nameIdentifier": "603", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60251930", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60251930"}, {"nameIdentifier": "60251930", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060251930"}]}, {"creatorNames": [{"creatorName": "川越, 信秀"}], "nameIdentifiers": [{"nameIdentifier": "25541", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "新井, 隆成"}], "nameIdentifiers": [{"nameIdentifier": "1442", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70547182", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000070547182"}]}, {"creatorNames": [{"creatorName": "井上, 正樹"}], "nameIdentifiers": [{"nameIdentifier": "20086", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10127186", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10127186"}, {"nameIdentifier": "10127186", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000010127186"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-SUZUKI-N-33.pdf", "filesize": [{"value": "244.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 244500.0, "url": {"label": "ME-PR-SUZUKI-N-33.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/14527/files/ME-PR-SUZUKI-N-33.pdf"}, "version_id": "6949b62e-f703-4a76-a101-c9e311c43b47"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "ピクノジェノール", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ビタミンE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "8-OHdG", "subitem_subject_scheme": "Other"}, {"subitem_subject": "喫煙", "subitem_subject_scheme": "Other"}, {"subitem_subject": "臨床試験", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pycnogenol®", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Vitamin E", "subitem_subject_scheme": "Other"}, {"subitem_subject": "8-hydroxy-2′-deoxyguanosine (8-OHdG)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "smoking", "subitem_subject_scheme": "Other"}, {"subitem_subject": "clinical trial", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "健常喫煙者における抗酸化天然成分によるパイロット試験：DNA 酸化傷害抑制効果の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "健常喫煙者における抗酸化天然成分によるパイロット試験：DNA 酸化傷害抑制効果の検討"}, {"subitem_title": "Pilot Study of Antioxidant Mixture (Vitamin E, Pycnogenol® and Squalene) in Healthy Smokers: Inhibitory Effect on Oxidative DNA Damage", "subitem_title_language": "en"}]}, "item_type_id": "4", "owner": "3", "path": ["1134"], "permalink_uri": "http://hdl.handle.net/2297/28429", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-03"}, "publish_date": "2017-10-03", "publish_status": "0", "recid": "14527", "relation": {}, "relation_version_is_last": true, "title": ["健常喫煙者における抗酸化天然成分によるパイロット試験：DNA 酸化傷害抑制効果の検討"], "weko_shared_id": -1}