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Alteration of Histone Tail Modifications in the Xist Locus in Wild-Type and Tsix-Mutant Male Embryonic Stem Cells during Differentiation
http://hdl.handle.net/2297/28451
http://hdl.handle.net/2297/284510b1bd1d9-b7cf-4757-8e31-c1cd61f5c17d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-YOKOTA-T-153.pdf (827.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Alteration of Histone Tail Modifications in the Xist Locus in Wild-Type and Tsix-Mutant Male Embryonic Stem Cells during Differentiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| その他のタイトル | ||||||
| 値 | 野生型および Tsix 遺伝子変異ES細胞の分化誘導時における Xist 遺伝子座ヒストン修飾の変化 | |||||
| 著者 |
Shibata, Shinwa
× Shibata, Shinwa× Yokota, Takashi |
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| 書誌情報 |
Experimental Animals 巻 57, 号 2, p. 153-157, 発行日 2008-04-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1341-1357 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11032321 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1538/expanim.57.153 | |||||
| 出版者 | ||||||
| 出版者 | 日本実験動物学会 = Japanese Association for Laboratory Animal Science | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The non-coding RNA Xist is indispensable for X chromosome inactivation. Transcriptional control of Xist gene depends on its antisense partner gene Tsix which prevents Xist up-regulation in cis. Previous studies proposed Tsix acts by regulating chromatin structure. Although histone modifications in the Xist locus during differentiation have been described in female embryonic stem (ES) cells, they remain unclear in males. Here we addressed histone modifications in the Xist locus in wild-type and Tsix-mutant male ES cells during differentiation. Their active and repressive modifications were attenuated upon differentiation, while the histone modification profile in males resembled that of females in an undifferentiated condition. These results provide implications in understanding the regulation of Xist gene, as well as other developmentally regulated genes, through chromatin structure. | |||||
| 権利 | ||||||
| 権利情報 | Copyright (c) 2008 日本実験動物学会 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jalas.jp/ | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ci.nii.ac.jp/naid/10024166348 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://japanlinkcenter.org/JST.JSTAGE/expanim/57.153 | |||||
