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絶食時のラットを用いたビペリデンの体内動態変動要因の解析
http://hdl.handle.net/2297/6255
http://hdl.handle.net/2297/6255f8725bdd-0f6b-4f1c-a6b0-efce06dbdddc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-ISHIZAKI-J-322.pdf (828.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | 絶食時のラットを用いたビペリデンの体内動態変動要因の解析 | |||||
| タイトル | ||||||
| タイトル | Analysis of Fasting Effect on Biperiden Distribution Kinetics in Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
石崎, 純子
× 石崎, 純子× 横川, 弘一× 中島, 恵美× 永野, 耐造× 前田, 均× 市村, 藤雄 |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 大学院自然科学研究科分子作用学 | |||||
| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医学部付属病院薬剤部 | |||||
| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学大学院医学系研究科 | |||||
| 書誌情報 |
病院薬学 巻 17, 号 5, p. 322-329, 発行日 1991-10-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0389-9098 | |||||
| 出版者 | ||||||
| 出版者 | 日本医療薬学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Analysis of fasting effect on biperiden distribution in rats was examined. The plasma concentration at 24hr after i. v. injection of 3.2 mg/kg varied between 0.4 ng/ml (10-week-old fasted rats) and 1.4 ng/ml (10-week-old normal rats). The steady state distribution volume of biperiden in the fasted rats was smaller by 2/3 than that in the normal rats. The determined percentage of fat tissue per body weight reduced from 7.6 to 2.35 was caused by fasting. There was a good cerrelation between the steady state distribution volume of biperiden per lean mass body weight and the fat volume per lean mass body weight (r=0.989) in four different groups (10-week-old fasted 4-, 10-, and 50-week-old normal rats). The fat/plasma concentration ratios at 8hr after the i. v. injection varied between 380 (10-week-old normal rats) and 550 (10-week-old fasted rats), whereas the brain/plasma concentration ratios were identical to those at steady state among the two groups. The time courses of biperiden concentration in plasma, brain, and fat were simulated using a physiological pharmacokinetic model. There was reasonable agreement between the model predictions and the observed data, suggesting that the change in the fat volume is a dominant determinant of the distribution volume of biperiden in rats. Changes in fasted tissue and plasma concentrations are discussed in relation to the clinical usefulness of the blood level monitoring. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
