| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-04 |
| タイトル |
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タイトル |
Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00015038 |
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ID登録タイプ |
JaLC |
| 著者 |
Ishizaki, Junko
Tsuda, Tomoko
Suga, Yukio
Ito, Satsuki
Arai, Kunizo
Sai, Yoshimichi
Miyamoto, Ken-ichi
|
| 著者別表示 |
石崎, 純子
菅, 幸生
荒井, 國三
崔, 吉道
宮本, 謙一
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| 書誌情報 |
Biological and Pharmaceutical Bulletin
巻 35,
号 7,
p. 1009-1013,
発行日 2012-07-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0918-6158 |
| NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10885497 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1248/bpb.b110639 |
| 出版者 |
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出版者 |
Pharmaceutical Society of Japan = 日本薬学会 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Changes of mycophenolic acid (MPA) pharmacokinetics with aging were investigated in rats. We also compared the effect of concomitant amoxicillin/clavulanate combination (CVA/AMPC) on the pharmacokinetics of MPA in 4-week-old and 12-week-old rats (the package insert of CVA/AMPC warns of possible interaction with MPA). Four-week-old rats showed a 1.4-fold higher total body clearance of MPA and a lower volume of distribution of MPA (65%), compared to the values in 12-week-old rats. However, the difference in MPA pharmacokinetics disappeared when enterohepatic circulation was eliminated by bile duct cannulation (BDC). Concomitant CVA/AMPC significantly reduced plasma MPA concentration in intact rats of both age groups, and the age-dependent difference of MPA pharmacokinetics was no longer apparent. The effect of CVA/AMPC was not seen in rats that had undergone BDC, suggesting that the drug-drug interaction can be attributed to inhibition of enterohepatic circulation by CVA/AMPC. These results indicate that the aging-related alteration of MPA pharmacokinetics is a consequence of immature enterohepatic circulation in 4-week-old rats. Higher doses of MPA may be necessary in juveniles. © 2012 The Pharmaceutical Society of Japan. |
| 権利 |
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権利情報 |
Copyright © 2012 The Pharmaceutical Society of Japan |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://japanlinkcenter.org/DN/JST.JSTAGE/bpb/b110639 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.pharm.or.jp/ |
PH-PR-ISHIZAKI-J-1009.pdf (624.3 kB)
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