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Antitumor Activity of Asterriquinones from Aspergillus Fungi. IV. An Attempt to modify the Structure of Asterriquinones to increase the Activity
http://hdl.handle.net/2297/34354
http://hdl.handle.net/2297/343543e33c9ef-92ea-468c-9ef8-c48d48e7e111
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-SHIMIZU-S-1896.pdf (470.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | Antitumor Activity of Asterriquinones from Aspergillus Fungi. IV. An Attempt to modify the Structure of Asterriquinones to increase the Activity | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Shimizu, Sakae
× Shimizu, Sakae× Yamamoto, Yuzuru× Koshimura, Saburo |
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| 書誌情報 |
Chemical & pharmaceutical bulletin 巻 30, 号 5, p. 1896-1899, 発行日 1982-05-25 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0009-2363 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00602100 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/cpb.30.1896 | |||||
| 出版者 | ||||||
| 出版者 | 日本薬学会 Pharmaceutical Society of Japan | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | An attempt was made to obtain more potent antitumor compounds by chemically modifying asterriquinones. Amino-and aziridinyl-asterriquinone were newly synthesized, but showed no activity. However, dimethylallylation of asterriquinone Cl, which had no effect in vivo, yielded an active compound, with a change in pKa value from 5.0 to 7.2. This suggests that other active compounds may be obtained by the chemical modification of asterriquinones with various other functional groups. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © The Pharmaceutical Society of Japan | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ci.nii.ac.jp/naid/110003634531/ | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.pharm.or.jp/ | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/cpb1958/30/5/30_5_1896/_article | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://japanlinkcenter.org/JST.Journalarchive/cpb1958/30.1896 | |||||
