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  1. J-7. 医薬保健研究域附属AIホスピタル・マクロシグナルダイナミクス研究開発センター
  2. j-7 10. 学術雑誌掲載論文
  3. 1. 査読済論文

A cross-sectional investigation of the quality of selected medicines in Cambodia in 2010.

https://doi.org/10.24517/00015091
https://doi.org/10.24517/00015091
69e75288-f0dc-41e9-9677-1332e307710a
名前 / ファイル ライセンス アクション
PH-PR-YOSHIDA-N-13.pdf PH-PR-YOSHIDA-N-13.pdf (446.6 kB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-10-04
タイトル
タイトル A cross-sectional investigation of the quality of selected medicines in Cambodia in 2010.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
ID登録
ID登録 10.24517/00015091
ID登録タイプ JaLC
著者 Yoshida, Naoko

× Yoshida, Naoko

WEKO 562
金沢大学研究者情報 20565428
研究者番号 20565428

Yoshida, Naoko

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Khan, Mohiuddin Hussain

× Khan, Mohiuddin Hussain

WEKO 27214

Khan, Mohiuddin Hussain

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Tabata, Hitomi

× Tabata, Hitomi

WEKO 27215

Tabata, Hitomi

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Dararath, Eav

× Dararath, Eav

WEKO 27216

Dararath, Eav

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Sovannarith, Tey

× Sovannarith, Tey

WEKO 27217

Sovannarith, Tey

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Kiet, Heng Bun

× Kiet, Heng Bun

WEKO 27218

Kiet, Heng Bun

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Nivanna, Nam

× Nivanna, Nam

WEKO 27219

Nivanna, Nam

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Akazawa, Manabu

× Akazawa, Manabu

WEKO 27220

Akazawa, Manabu

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Tsuboi, Hirohito

× Tsuboi, Hirohito

WEKO 27221
金沢大学研究者情報 20319338
研究者番号 20319338

Tsuboi, Hirohito

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Tanimoto, Tsuyoshi

× Tanimoto, Tsuyoshi

WEKO 1475
金沢大学研究者情報 80142123
研究者番号 80142123

Tanimoto, Tsuyoshi

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Kimura, Kazuko

× Kimura, Kazuko

WEKO 76136
e-Rad 80324094

Kimura, Kazuko

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著者別表示 吉田, 直子

× 吉田, 直子

吉田, 直子

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赤沢, 学

× 赤沢, 学

赤沢, 学

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坪井, 宏仁

× 坪井, 宏仁

坪井, 宏仁

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谷本, 剛

× 谷本, 剛

谷本, 剛

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木村, 和子

× 木村, 和子

木村, 和子

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書誌情報 BMC pharmacology & toxicology

巻 15, 号 1, p. 13, 発行日 2014-01-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 2050-6511
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1186/2050-6511-15-13
出版者
出版者 BioMed Central
抄録
内容記述タイプ Abstract
内容記述 Access to good-quality medicines in many countries is largely hindered by the rampant circulation of spurious/falsely labeled/falsified/counterfeit (SFFC) and substandard medicines. In 2006, the Ministry of Health of Cambodia, in collaboration with Kanazawa University, Japan, initiated a project to combat SFFC medicines. To assess the quality of medicines and prevalence of SFFC medicines among selected products, a cross-sectional survey was carried out in Cambodia. Cefixime, omeprazole, co-trimoxazole, clarithromycin, and sildenafil were selected as candidate medicines. These medicines were purchased from private community drug outlets in the capital, Phnom Penh, and Svay Rieng and Kandal provinces through a stratified random sampling scheme in July 2010. In total, 325 medicine samples were collected from 111 drug outlets. Non-licensed outlets were more commonly encountered in rural than in urban areas (p < 0.01). Of all the samples, 93.5% were registered and 80% were foreign products. Samples without registration numbers were found more frequently among foreign-manufactured products than in domestic ones (p < 0.01). According to pharmacopeial analytical results, 14.5%, 4.6%, and 24.6% of the samples were unacceptable in quantity, content uniformity, and dissolution test, respectively. All the ultimately unacceptable samples in the content uniformity tests were of foreign origin. Following authenticity investigations conducted with the respective manufacturers and medicine regulatory authorities, an unregistered product of cefixime collected from a pharmacy was confirmed as an SFFC medicine. However, the sample was acceptable in quantity, content uniformity, and dissolution test. The results of this survey indicate that medicine counterfeiting is not limited to essential medicines in Cambodia: newer-generation medicines are also targeted. Concerted efforts by both domestic and foreign manufacturers, wholesalers, retailers, and regulatory authorities should help improve the quality of medicines.
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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