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Radiolabeled apoptosis imaging agents for early detection of response to therapy
https://doi.org/10.24517/00015092
https://doi.org/10.24517/000150926b4b3c98-e1a7-4139-aef7-a47607281b6a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-OGAWA-K-732603.pdf (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2017-10-04 | |||||||
| タイトル | ||||||||
| タイトル | Radiolabeled apoptosis imaging agents for early detection of response to therapy | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00015092 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Ogawa, Kazuma
× Ogawa, Kazuma× Aoki, Miho |
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| 著者別表示 |
小川, 数馬
× 小川, 数馬
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学新学術創成研究機構 / 金沢大学医薬保健研究域薬学系 | |||||||
| 書誌情報 |
Scientific World Journal 巻 2014, p. 732603, 発行日 2014-01-01 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 2356-6140 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1155/2014/732603 | |||||||
| 出版者 | ||||||||
| 出版者 | Hindawi Publishing Corporation | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Since apoptosis plays an important role in maintaining homeostasis and is associated with responses to therapy, molecular imaging of apoptotic cells could be useful for early detection of therapeutic effects, particularly in oncology. Radiolabeled annexin V compounds are the hallmark in apoptosis imaging in vivo. These compounds are reviewed from the genesis of apoptosis (cell death) imaging agents up to recent years. They have some disadvantages, including slow clearance and immunogenicity, because they are protein-based imaging agents. For this reason, several studies have been conducted in recent years to develop low molecule apoptosis imaging agents. In this review, radiolabeled phosphatidylserine targeted peptides, radiolabeled bis(zinc(II)-dipicolylamine) complex, radiolabeled 5-fluoropentyl-2-methyl-malonic acid (ML-10), caspase-3 activity imaging agents, radiolabeled duramycin, and radiolabeled phosphonium cation are reviewed as promising low-molecular-weight apoptosis imaging agents. | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
