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2-Thio-6-methyluracilのラットにおける代謝について
http://hdl.handle.net/2297/34887
http://hdl.handle.net/2297/348879ed0eb36-a687-443e-970b-938bea77b34d
名前 / ファイル | ライセンス | アクション |
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PH-PR-SHIMIZU-S-332.pdf (755.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-04 | |||||
タイトル | ||||||
タイトル | 2-Thio-6-methyluracilのラットにおける代謝について | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Studies on the Metabolism of 2-Thio-6-methyluracil in Rats | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
加野, 軒作
× 加野, 軒作× 植竹, 厚子× 清水, 栄× 新田, 啓一× 山本, 譲 |
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書誌情報 |
藥學雜誌 巻 94, 号 3, p. 332-337, 発行日 1974-03-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0031-6903 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00284903 | |||||
出版者 | ||||||
出版者 | 日本薬学会 Pharmaceutical Society of Japan | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Metabolism of 6-methyl-2-thiouracil was studied in rats by using ^<14>C-labeled compound. Following the oral administration of 6-methyl-2-thiouracil [2-^<14>C] (490 mg/kg), the about 68% of the administered radioactivity was excreted in urine, 27% in feces, and 1.2% in respiratory CO_2 within 72 hr. After oral ingestion of the radioactive compound, radioactive substances excreted in urine after 48 hr were 6-methyl-2-thiouracil, 6-methyl-uracil, 6-methyl-2-methylthiouracil, 6-methyl-4-oxo-pyrimidine, 2-amino-6-methyl-4-oxopyrimidine, and urea which were present in about 46.2,9.1,1.6,1.8,0.2,and 0.8% of total radioactivity in the urine, respectively. In in vitro tests using rat liver slices, radioactivity was also detected in 5,6-dihydro-6-methyluracil along with the above metabolites. | |||||
権利 | ||||||
権利情報 | Copyright © by the PHARMACEUTICAL SOCIETY OF JAPAN | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://ci.nii.ac.jp/naid/110003651918/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://japanlinkcenter.org/JST.Journalarchive/yakushi1947/94.332 |