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Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells
https://doi.org/10.24517/00015277
https://doi.org/10.24517/000152778aa63988-a279-43fd-af05-341fc60f158f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-NAKANISHI-Y-3868.pdf (10.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-10-04 | |||||||||
| タイトル | ||||||||||
| タイトル | Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00015277 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Kuraishi, Takayuki
× Kuraishi, Takayuki× Nakagawa, Yukiko× Nagaosa, Kazushige× Hashimoto, Yumi× Ishimoto, Takashi× Moki, Takeshi× Fujita, Yu× Nakayama, Hiroshi× Dohmae, Naoshi× Shiratsuchi, Akiko× Yamamoto, Nakako× Ueda, Koichi× Yamagichi, Masamitsu× Awasaki, Takeshi× Nakanishi, Yoshinobu |
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| 著者別表示 |
永長, 一茂
× 永長, 一茂
× 中西, 義信
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学医薬保健研究域薬学系 | |||||||||
| 書誌情報 |
EMBO Journal 巻 28, 号 4, p. 3868-3878, 発行日 2009-12-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0261-4189 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA10627582 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1038/emboj.2009.343 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Nature Publishing Group | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Phagocytic removal of cells undergoing apoptosis is necessary for animal development and tissue homeostasis. Draper, a homologue of the Caenorhabditis elegans phagocytosis receptor CED-1, is responsible for the phagocytosis of apoptotic cells in Drosophila, but its ligand presumably present on apoptotic cells remains unknown. An endoplasmic reticulum protein that binds to the extracellular region of Draper was isolated. Loss of this protein, which we name Pretaporter, led to a reduced level of apoptotic cell clearance in embryos, and the overexpression of pretaporter in the mutant flies rescued this defect. Results from genetic analyses suggested that Pretaporter functionally interacts with Draper and the corresponding signal mediators. Pretaporter was exposed at the cell surface after the induction of apoptosis, and cells artificially expressing Pretaporter at their surface became susceptible to Draper-mediated phagocytosis. Finally, the incubation with Pretaporter augmented the tyrosine-phosphorylation of Draper in phagocytic cells. These results collectively suggest that Pretaporter relocates from the endoplasmic reticulum to the cell surface during apoptosis to serve as a ligand for Draper in the phagocytosis of apoptotic cells. © 2009 European Molecular Biology Organization. | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
