| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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|
タイトル |
Virological effects and safety of combined double filtration plasmapheresis (DFPP) and interferon therapy in patients with chronic hepatitis C: A preliminary study |
| 言語 |
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言語 |
eng |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00026597 |
|
ID登録タイプ |
JaLC |
| 著者 |
Yamashita, Tatsuya
Arai, Kuniaki
Sakai, Akito
Mizukoshi, Eishiro
Sakai, Yoshio
Kagaya, Takashi
Nakamoto, Yasunari
Honda, Masao
Wada, Takashi
Yokoyama, Hitoshi
Kaneko, Shuichi
|
| 著者別表示 |
山下, 竜也
荒井, 邦明
水腰, 英四郎
酒井, 佳夫
加賀谷, 尚史
中本, 安成
本多, 政夫
和田, 隆志
横山, 仁
金子, 周一
|
| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学先進予防医学研究センター / 金沢大学医学部附属病院内科 |
| 書誌情報 |
Hepatology Research
巻 36,
号 3,
p. 167-175,
発行日 2006-11-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1386-6346 |
| DOI |
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|
関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.hepres.2006.07.013 |
| 出版者 |
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出版者 |
Elsevier BV |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: In patients with chronic genotype 1b hepatitis C and a high viral load, the viral load was reduced by double filtration plasmapheresis (DFPP), followed by combined interferon and ribavirin therapy. The safety and virological effects of this treatment method were preliminarily investigated. Methods: In nine patients with chronic hepatitis C, DFPP was performed three times on days 1, 2, and 4, and the administration of interferon and ribavirin was initiated immediately after DFPP on day 1. Result: The HCV RNA was undetectable in all patients after the plasma was passed through a plasma fractionator (second filter) in the DFPP circuit. After 2 weeks, the HCV RNA tended to decrease in the DFPP group more than in the control group (-2.45 ± 1.12 versus -1.57 ± 0.95, P = 0.073). However, this decrease was not attributable to a sustained virological response (SVR) (22.2% versus 18.2%, P = 0.822). Most of the adverse events were caused by the interferon and ribavirin combination therapy. Conclusion: DFPP can be safely performed concomitantly with interferon and ribavirin combination therapy in chronic hepatitis C patients. The combination may contribute to an early virological response. The effect of DFPP on the SVR and its significance remain to be clarified. © 2006 Elsevier Ireland Ltd. All rights reserved. |
| 著者版フラグ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
HP-PR-YAMASHITA-T-01.pdf (296.4 kB)
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