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Inhibition of invasion and metastasis in oral cancer by targeting urokinase-type plasminogen activator receptor
http://hdl.handle.net/2297/1834
http://hdl.handle.net/2297/183498555a65-db98-44d3-8881-4c362d1ace82
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
nozaki3.pdf (827.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-05 | |||||
| タイトル | ||||||
| タイトル | Inhibition of invasion and metastasis in oral cancer by targeting urokinase-type plasminogen activator receptor | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Nozaki, Shinichi
× Nozaki, Shinichi× Endo, Yoshio× Nakahara, Hirokazu× Yoshizawa, Kunio× Hashiba, Yukari× Kawashiri, Shuichi× Tanaka, Akira× Nakagawa, Kiyomasa× Matsuoka, Yudai× Kogo, Mikihiko× Yamamoto, Etsuhide |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医学部附属病院 | |||||
| 書誌情報 |
Oral Oncology 巻 41, 号 10, p. 971-977, 発行日 2005-11-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1368-8375 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.oraloncology.2005.05.013 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | There have been reports of strong correlations between poor prognosis in various cancers and concomitant expression of urokinase-type plasminogen activator (uPA) and its surface receptor (uPAR). We and others have previously shown that the uPA system plays a significant role in a subset of head and neck squamous cell carcinoma. In the present study, we found that uPAR is required for invasion and metastasis of highly malignant oral cancer cells (OSC-19). Treating OSC-19 cells with antisense oligonucleotides (AS) targeting uPAR resulted in a dramatic decrease of uPAR mRNA expression. Furthermore, pretreatment with AS or siRNA targeting uPAR inhibited progression of OSC-19 cells in experimental models. These results suggest that overexpression of uPAR increases the invasiveness and metastasis of OSC-19 cells, and that uPAR is a promising therapeutic target for regulation of progression of oral cancer. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
