| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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タイトル |
Assessment of Olfactory Nerve by SPECT-MRI Image with Nasal Thallium-201 Administration in Patients with Olfactory Impairments in Comparison to Healthy Volunteers |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00026790 |
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ID登録タイプ |
JaLC |
| 著者 |
Shiga, Hideaki
Taki, Junichi
Washiyama, Kohshin
Yamamoto, Junpei
Kinase, Sakae
Okuda, Koichi
Kinuya, Seigo
Watanabe, Naoto
Tonami, Hisao
Koshida, Kichiro
Amano, Ryohei
Furukawa, Mitsuru
Miwa, Takaki
|
| 著者別表示 |
志賀, 英明
瀧, 淳一
鷲山, 幸信
絹谷, 清剛
渡邉, 直人
利波, 久雄
越田, 吉郎
天野, 良平
古川, 仞
三輪, 高喜
|
| 書誌情報 |
PLoS ONE
巻 8,
号 2,
p. e57671,
発行日 2013-02-02
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1932-6203 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1371/journal.pone.0057671 |
| 出版者 |
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出版者 |
PLoS ONE |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Purpose: The aim of this study was to assess whether migration of thallium-201 (201Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of 201Tl. Procedures: 10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26-71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). 201TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. 201Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry. Results: Nasal201Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of 201Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included. Conclusions: Assessment of the 201Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction. © 2013 Shiga et al. |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
HO-PR-TAKI-J-057671.pdf (2.3 MB)
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