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カラムスイッチングHPLCシステムによるゾニサミドの高感度測定法の評価
http://hdl.handle.net/2297/39138
http://hdl.handle.net/2297/3913836bb9c67-29ff-4d71-9b05-e24f27da3ca5
名前 / ファイル | ライセンス | アクション |
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PH-PR-SHIMADA-T-178.pdf (720.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | カラムスイッチングHPLCシステムによるゾニサミドの高感度測定法の評価 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Evaluation of a Highly Sensitive Measurement Method of Zonisamide by an HPLCSystem with Column-Switching | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
金, 明姫
× 金, 明姫× 西尾, 忠× 嶋田, 努× 竹田, 和喜× 横川, 弘一× 宮本, 謙一 |
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書誌情報 |
医療薬学 = Japanese journal of pharmaceutical health care and sciences 巻 29, 号 2, p. 178-183, 発行日 2003-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-342X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11527197 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.5649/jjphcs.29.178 | |||||
出版者 | ||||||
出版者 | 日本医療薬学会 = Japanese Society of Pharmaceutical Health Care and Sciences | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A fully automated high-performance liquid chromatography system with column-switching was evaluated to determine the concentration of zonisamide (ZNS) in human plasma. After the plasma sample was diluted to 10-times with the mobile phase, the sample (101μL) was injected into the column-switching system without pretreatment. ZNS was detected by ultraviolet absorption at 246 nm. The calibration curve of ZNS was linear and ranged from 1.57 to 50μg/mL of plasma. The coefficients of variation in the within-run (n=5) and the between-run (5 days) precisions of ZNS were below 5 %. The limit of quantification was 0.5pg/mL in 1 μL of human plasma. A good correlation was found between the data obtained by this system and the ELISA system using Markit-M Excegran (r=0.956) or the solid-phase-extraction HPLC method (r=0.985). This system for ZNS is thus considered to be a very useful measurement for therapeutic drug monitoring because of its high sensitivity, rapidity and low cost compared with other measurement systems. | |||||
権利 | ||||||
権利情報 | Copyright © JSPHCS. 日本医療薬学会 Japanese Society of Pharmaceutical Health Care and Sciences | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jsphcs.jp/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/jjphcs/-char/ja |