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Effects of green tea fractions on oxygen-induced retinal neovascularization in the neonatal rat
http://hdl.handle.net/2297/39143
http://hdl.handle.net/2297/39143a32d9451-0b28-485c-933c-7bcd454c08bb
| 名前 / ファイル | ライセンス | アクション |
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PH-PR-SHIMADA-T-43.pdf (580.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-05 | |||||
| タイトル | ||||||
| タイトル | Effects of green tea fractions on oxygen-induced retinal neovascularization in the neonatal rat | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Saito, Yuta
× Saito, Yuta× Hasebe-Takenaka, Yasuko× Ueda, Toshihiko× Nakanishi-Ueda, Takako× Kosuge, Shotaro× Aburada, Masaki× Shimada, Tsutomu× Ikeya, Yukinobu× Onda, Hidetoshi× Ogura, Hirotsugu× Taguchi, Yoko× Yasuhara, Hajime× Koide, Ryohei |
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| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 41, 号 1, p. 43-49, 発行日 2007-07-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 10.3164/jcbn.2007006 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10710201 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3164/jcbn.2007006 | |||||
| 出版者 | ||||||
| 出版者 | 日本酸化ストレス学会 = The Society for Free Radical Research Japan | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study aimed to investigate the preventive effects of green tea fractions (GTFs) on rat model of oxygen-induced retinopathy (OIR). Neonatal Sprague-Dawley rats were exposed to daily cycles of 80% oxygen (20.5 h), ambient air (0.5 h), and progressive return to 80% oxygen (3 h) until postnatal day 12 (P12), then the rats were placed in ambient air until P18. The green tea was fractionated by DM-A50, DM-W, M-B, and M-W. The rats were treated once daily from P6 to P17 by gastric gavage of GTFs (0.05 or 0.01 g/ml) or distilled water (DW) at 50 μl/10 g body weight. On P18, the rats were sacrificed and the retinal samples were collected. The retinal neovascularization (NV) was scored and avascular areas (AVAs) were measured as a % of total retinal area (%AVAs) in ADPase stained retinas. The NV scores in 0.01 g/ml M-W were significantly lower than those in DW. The %AVAs in 0.05 g/ml DM-A50 and in 0.05 g/ml and 0.01 g/ml M-W were significantly lower than those in DW. There were less catechins, and less caffeine in M-W fraction compared with other GTFs, suggesting components of green tea except for catechins and caffeine might suppress the neovascularization in rat model of OIR. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2007 by The Editorial Secretariat of JCBN | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/jcbn | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | http://sfrrj.umin.jp/ | |||||
