| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
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|
タイトル |
Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00027022 |
|
ID登録タイプ |
JaLC |
| 著者 |
Katsuda, Hiromu
Yamashita, Mariko
Katsura, Hideyuki
Yu, Jia
Waki, Yoshihiro
Nagata, Naoto
Sai, Yoshimichi
Miyamoto, Kenichi
|
| 著者別表示 |
長田, 直人
崔, 吉道
宮本, 謙一
|
| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学附属病院薬剤部 |
| 書誌情報 |
Biological and Pharmaceutical Bulletin
巻 33,
号 11,
p. 1867-1871,
発行日 2010-01-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0918-6158 |
| NCID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10885497 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1248/bpb.33.1867 |
| 出版者 |
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出版者 |
Pharmaceutical Society of Japan = 日本薬学会 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The present study examined the influence of cimetidine on the nephrotoxicity and antitumor effects of cisplatin in vitro and in vivo. When the serum concentration of cimetidine was maintained over 20 μg/ml for 4 h by bolus and continuous intravenous infusion, cimetidine prevented nephrotoxicity of cisplatin without influencing antitumor activity. Cimetidine and the antioxidant N-acetylcysteine (NAC) significantly inhibited the in vitro growth inhibition of cisplatin in cells originating from the kidney, but not in SOSN2 osteosarcoma cells. Cimetidine (1mM) also did not influence platinum concentration in the cells, regardless of whether the organic cation transporter 2 (OCT2) was expressed. Cisplatin did induce reactive oxygen species (ROS) in the KN41 kidney cell line and cimetidine and NAC significantly reduced ROS production. However, cisplatin did not produce ROS in osteosarcoma cells. From these results, cimetidine clearly inhibits nephrotoxicity induced by cisplatin without any influence on the antitumor activity of cisplatin on osteosarcoma in vitro and in vivo. © 2010 Pharmaceutical Society of Japan. |
| 権利 |
|
|
権利情報 |
(c) 2010 The Pharmaceutical Society of Japan |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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|
識別子タイプ |
URI |
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|
関連識別子 |
http://www.jstage.jst.go.jp/article/bpb/33/11/33_1867/_article |
PH-PR-MIYAMOTO-K-1867.pdf (262.1 kB)
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