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Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.
https://doi.org/10.24517/00027425
https://doi.org/10.24517/000274251ac7f011-1a14-4ec8-ac00-2b967d14aca5
| 名前 / ファイル | ライセンス | アクション |
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CA-PR-OSHIMA-M-1671.pdf (5.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2017-10-05 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells. | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| ID登録 | ||||||||||||||||
| ID登録 | 10.24517/00027425 | |||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||
| 著者 |
Oguma, Keisuke
× Oguma, Keisuke× Oshima, Hiroko× Aoki, Masahiro× Uchio, Ryusei× Naka, Kazuhito× Nakamura, Satoshi× Hirao, Atsushi× Saya, Hideyuki× Taketo, Makoto Mark× Oshima, Masanobu |
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| 著者別表示 |
小熊, 圭祐
× 小熊, 圭祐
× 大島, 浩子
× 仲, 一仁
× 平尾, 敦
× 大島, 正伸
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| 提供者所属 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | 金沢大学がん研究所がん幹細胞研究センター | |||||||||||||||
| 書誌情報 |
The EMBO journal 巻 27, 号 12, p. 1671-1681, 発行日 2008-06-18 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 1460-2075 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1038/emboj.2008.105 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Nature Publishing Group | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | The activation of Wnt/β-catenin signalling has an important function in gastrointestinal tumorigenesis. It has been suggested that the promotion of Wnt/β-catenin activity beyond the threshold is important for carcinogenesis. We herein investigated the role of macrophages in the promotion of Wnt/β-catenin activity in gastric tumorigenesis. We found β-catenin nuclear accumulation in macrophage-infiltrated dysplastic mucosa of the K19-Wnt1 mouse stomach. Moreover, macrophage depletion in Apc Δ716 mice resulted in the suppression of intestinal tumorigenesis. These results suggested the role of macrophages in the activation of Wnt/β-catenin signalling, which thus leads to tumour development. Importantly, the conditioned medium of activated macrophages promoted Wnt/β-catenin signalling in gastric cancer cells, which was suppressed by the inhibition of tumour necrosis factor (TNF)-α. Furthermore, treatment with TNF-α induced glycogen synthase kinase 3β (GSK3β) phosphorylation, which resulted in the stabilization of β-catenin. We also found that Helicobacter infection in the K19-Wnt1 mouse stomach caused mucosal macrophage infiltration and nuclear β-catenin accumulation. These results suggest that macrophage-derived TNF-α promotes Wnt/β-catenin signalling through inhibition of GSK3β, which may contribute to tumour development in the gastric mucosa. © 2008 European Molecular Biology Organization | All Rights Reserved. | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
