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Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy
https://doi.org/10.24517/00027440
https://doi.org/10.24517/000274400f3773db-2a36-41d6-822c-a779f6d39c68
| 名前 / ファイル | ライセンス | アクション |
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CA-PR-MINAMOTO-T-1363.pdf (780.2 kB)
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CA-PR-MINAMOTO-T-Supporting information.pdf (139.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2017-10-05 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| ID登録 | ||||||||||||||||
| ID登録 | 10.24517/00027440 | |||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||
| 著者 |
Domoto, Takahiro
× Domoto, Takahiro× Pyko, Ilya V.× Furuta, Takuya× Miyashita, Katsuyoshi× Uehara, Masahiro× Shimasaki, Takeo× Nakada, Mitsutoshi× Minamoto, Toshinari |
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| 著者別表示 |
堂本, 貴寛
× 堂本, 貴寛
× 宮下 , 勝吉
× 島崎, 猛夫
× 中田, 光俊
× 源, 利成
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| 書誌情報 |
Cancer Science 巻 107, 号 10, p. 1363-1372, 発行日 2016-10-01 |
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| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 1347-9032 | |||||||||||||||
| NCID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA11808050 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1111/cas.13028 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Japanese Cancer Association / Blackwell Publishing Ltd | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Tumor cell invasion and resistance to therapy are the most intractable biological characteristics of cancer and, therefore, the most challenging for current cancer research and treatment paradigms. Refractory cancers, including pancreatic cancer and glioblastoma, show an inextricable association between the highly invasive behavior of tumor cells and their resistance to chemotherapy, radiotherapy and targeted therapies. These aggressive properties of cancer share distinct cellular pathways that are connected to each other by several molecular hubs. There is increasing evidence to show that glycogen synthase kinase (GSK)-3β is aberrantly activated in various cancer types and this has emerged as a potential therapeutic target. In many but not all cancer types, aberrant GSK3β sustains the survival, immortalization, proliferation and invasion of tumor cells, while also rendering them insensitive or resistant to chemotherapeutic agents and radiation. Here we review studies that describe associations between therapeutic stimuli/resistance and the induction of pro-invasive phenotypes in various cancer types. Such cancers are largely responsive to treatment that targets GSK3β. This review focuses on the role of GSK3β as a molecular hub that connects pathways responsible for tumor invasion and resistance to therapy, thus highlighting its potential as a major cancer therapeutic target. We also discuss the putative involvement of GSK3β in determining tumor cell stemness that underpins both tumor invasion and therapy resistance, leading to intractable and refractory cancer with dismal patient outcomes. © 2016 Japanese Cancer Association. | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | (Please refer to a different file for the Supporting information of this article.) | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | © 2016 Japanese Cancer Association. | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
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| 識別子タイプ | URI | |||||||||||||||
| 関連識別子 | http://www.jca.gr.jp/ | |||||||||||||||
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| 識別子タイプ | URI | |||||||||||||||
| 関連識別子 | http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1349-7006 | |||||||||||||||
