| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-05 |
| タイトル |
|
|
タイトル |
Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00027499 |
|
ID登録タイプ |
JaLC |
| 著者 |
Motani, Kou
Kawase, Kouji
Imamura, Ryu
Kinoshita, Takeshi
Kushiyama, Hiroko
Suda, Takashi
|
| 著者別表示 |
今村, 龍
木下, 健
須田, 貴司
|
| 書誌情報 |
Cancer Science
巻 101,
号 8,
p. 1822-1827,
発行日 2010-08-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1347-9032 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11808050 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/j.1349-7006.2010.01610.x |
| 出版者 |
|
|
出版者 |
Japanese Cancer Association / Blackwell Publishing Ltd |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The adaptor protein ASC (also called TMS1) links certain NLR proteins (e.g., NLRC4, NLRP3) and caspases. It is involved in the chemosensitivity of tumor cells and inflammation. Here, we found that ASC activation using NLRC4 mimicry or an autoinflammatory disease-associated NLRP3 mutant induced necrosis in COLO205 colon adenocarcinoma cells, but induced caspase-8-dependent apoptosis in NUGC-4 stomach cancer cells. As the Fas ligand induced caspase-8-dependent apoptosis in COLO205 cells, caspase-8 was intact in this cell line. ASC-mediated necrosis was preceded by lysosomal leakage, and diminished by inhibitors for vacuolar H+-ATPase, cathepsins, and calpains but not by inhibitors for caspase-8, or aspartic proteases, suggesting that lysosomes and certain proteases were involved in this process. Finally, growing tumors of transplanted human cancer cells in nude mice were eradicated by the activation of endogenous ASC in the tumor cells, irrespective of the form of cell death. Thus, ASC mediates distinct forms of cell death in different cell types, and is a promising target for cancer therapy. (Cancer Sci 2010). © 2010 Japanese Cancer Association. |
| 権利 |
|
|
権利情報 |
© Japanese Cancer Association 日本癌学会 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.jca.gr.jp/ |
CA-PR-SUDA-T-1822.pdf (522.3 kB)
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