| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-01-05 |
| タイトル |
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タイトル |
Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00049675 |
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ID登録タイプ |
JaLC |
| 著者 |
Ogawa, Kazuma
Ishizaki, Atsushi
Takai, Kenichiro
Kitamura, Yoji
Makino, Akira
Kozaka, Takashi
Kiyono, Yasushi
Shiba, Kazuhiro
Odani, Akira
|
| 著者別表示 |
小川, 数馬
北村, 陽二
小阪, 孝史
柴, 和弘
小谷, 明
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学新学術創成研究機構 |
| 書誌情報 |
Scientific Reports
巻 7,
号 1,
p. 13971,
発行日 2017-12-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2045-2322 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-017-14149-7 |
| 出版者 |
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出版者 |
Nature Publishing Group |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
67Ga-DOTA-(L-Asp)11 and 67Ga-DOTA-(L-Asp)14, which have been developed as bone imaging agents, showed a high accumulation in bone and a rapid blood clearance in mice. However, peptides composed of D-amino acids are more stable in vivo than those composed of their L-equivalents. In this study, 67Ga-DOTA-(D-Asp)n (n = 2, 5, 8, 11, or 14) were synthesized using the Fmoc-based solid-phase methodology and evaluated. In hydroxyapatite binding assay, binding of 67Ga-DOTA-(D-Asp)n tended to increase with increasing length of the amino acid chain. 67Ga-DOTA-(D-Asp)11 and 67Ga-DOTA-(D-Asp)14 caused a high accumulation of radioactivity in the bones of the mice. However, the results for 67Ga-DOTA-(D-Asp)n and 67Ga-DOTA-(L-Asp)n were comparable. In urine analyses, the proportion of intact complex after injection of 67Ga-DOTA-(D-Asp)14 was significantly higher than that of 67Ga-DOTA-(L-Asp)14. Although 67Ga-DOTA-(D-Asp)14 was more stable than 67Ga-DOTA-(L-Asp)14, the properties of 67Ga-DOTA-(D-Asp)n and 67Ga-DOTA-(L-Asp)n as bone imaging agents may be comparable. © 2017 The Author(s). |
| 権利 |
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|
権利情報 |
Copyright © 2017 The Author(s). |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FR-PR-OGAWA-K-13971.pdf (1.0 MB)
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