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Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone
https://doi.org/10.24517/00049675
https://doi.org/10.24517/00049675c24e1115-ec9f-4154-97df-793e0fb82cfb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FR-PR-OGAWA-K-13971.pdf (1.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2018-01-05 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| ID登録 | ||||||||||||||||
| ID登録 | 10.24517/00049675 | |||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||
| 著者 |
Ogawa, Kazuma
× Ogawa, Kazuma× Ishizaki, Atsushi× Takai, Kenichiro× Kitamura, Yoji× Makino, Akira× Kozaka, Takashi× Kiyono, Yasushi× Shiba, Kazuhiro× Odani, Akira |
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| 著者別表示 |
小川, 数馬
× 小川, 数馬
× 北村, 陽二
× 小阪, 孝史
× 柴, 和弘
× 小谷, 明
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| 提供者所属 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | 金沢大学新学術創成研究機構 | |||||||||||||||
| 書誌情報 |
Scientific Reports 巻 7, 号 1, p. 13971, 発行日 2017-12-01 |
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| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 2045-2322 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1038/s41598-017-14149-7 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Nature Publishing Group | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | 67Ga-DOTA-(L-Asp)11 and 67Ga-DOTA-(L-Asp)14, which have been developed as bone imaging agents, showed a high accumulation in bone and a rapid blood clearance in mice. However, peptides composed of D-amino acids are more stable in vivo than those composed of their L-equivalents. In this study, 67Ga-DOTA-(D-Asp)n (n = 2, 5, 8, 11, or 14) were synthesized using the Fmoc-based solid-phase methodology and evaluated. In hydroxyapatite binding assay, binding of 67Ga-DOTA-(D-Asp)n tended to increase with increasing length of the amino acid chain. 67Ga-DOTA-(D-Asp)11 and 67Ga-DOTA-(D-Asp)14 caused a high accumulation of radioactivity in the bones of the mice. However, the results for 67Ga-DOTA-(D-Asp)n and 67Ga-DOTA-(L-Asp)n were comparable. In urine analyses, the proportion of intact complex after injection of 67Ga-DOTA-(D-Asp)14 was significantly higher than that of 67Ga-DOTA-(L-Asp)14. Although 67Ga-DOTA-(D-Asp)14 was more stable than 67Ga-DOTA-(L-Asp)14, the properties of 67Ga-DOTA-(D-Asp)n and 67Ga-DOTA-(L-Asp)n as bone imaging agents may be comparable. © 2017 The Author(s). | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | Copyright © 2017 The Author(s). | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
