| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-01-11 |
| タイトル |
|
|
タイトル |
A 4-year trial of simvastatin in the treatment of patients with heterozygous familial hypercholesterolemia |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00049722 |
|
ID登録タイプ |
JaLC |
| 著者 |
Kitatani, Masako
Koizumi, Junji
Inazu, Akihiro
Kajinami, Kouji
Mabuchi, Hiroshi
|
| 著者別表示 |
小泉, 順二
稲津, 明広
梶波, 康二
馬渕, 宏
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域保健学系 |
| 書誌情報 |
Topics in Catalysis
巻 57,
号 1,
p. 62-71,
発行日 1996-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0011-393X |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00622254 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/S0011-393X(96)80031-2 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A study was conducted to determine the clinical efficacy and tolerability of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase in seven patients with heterozygous familial hypercholesterolemia (FH) (defined as primary hypercholesterolemia with tendon xanthoma or primary hypercholesterolemia without tendon xanthomas and at least one first-degree relative with familial hypercholesterolemia). These patients were administrated 10 mg/d of simvastatin for up to 4 years. Simvastatin significantly reduced levels of both total cholesterol and low-density lipoprotein cholesterol during treatment; respective reduction rates were 28% and 34% after 1 month and 32% and 40% after 4 years. Serum high-density lipoprotein cholesterol levels slightly and insignificantly increased. Serum triglyseride levels fell significantly by 24% at month 6. After this study, all xanthomas had reduced in size. No adverse events related to simvastatin were observed. We conclude that long-term simvastatin therapy is clinically useful and well tolerated in patients with FH. Copyright © 1985 Published by Elsevier Inc. |
| 権利 |
|
|
権利情報 |
Copyright © 1985 Published by Elsevier Inc. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.elsevier.com/locate/issn/0011393X |
|
|
関連名称 |
http://www.elsevier.com/locate/issn/0011393X |
ME-PR-INAZU-A-62 (503.4 kB)
.png)
