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Expression of basic fibroblast growth factor and its receptor in human pancreatic carcinomas
https://doi.org/10.24517/00049832
https://doi.org/10.24517/00049832869b920e-ca0f-416c-9f50-4ace26e9b3f9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-ISEKI-S-824.pdf (3.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2018-01-25 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Expression of basic fibroblast growth factor and its receptor in human pancreatic carcinomas | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| ID登録 | ||||||||||||||||||||||
| ID登録 | 10.24517/00049832 | |||||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||||
| 著者 |
Ohta, Tetsuo
× Ohta, Tetsuo× Yamamoto, Miyuki× Numata, Masayuki× Iseki, Shoichi× Tsukioka, Yuhji× Miyashita, Tomoharu× Kayahara, Masato× Nagakawa, Takukazu× Miyazaki, Itsuo× Nishikawa, Katsuzo× Yoshitake, Yoshino |
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| 著者別表示 |
太田, 哲生
× 太田, 哲生
× 山本, 美由紀
× 井関, 尚一
× 宮下, 知治
× 萱原, 正都
× 永川, 宅和
× 宮崎, 逸夫
× 西川, 克三
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| 提供者所属 | ||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||||||||||||||||
| 書誌情報 |
British Journal of Cancer 巻 72, 号 4, p. 824-831, 発行日 1995-10 |
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| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 0007-0920 | |||||||||||||||||||||
| NCID | ||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA00574355 | |||||||||||||||||||||
| DOI | ||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | 10.1038/bjc.1995.420 | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | Cancer Research UK | |||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | We examined the expression of basic fibroblast growth factor (FGF) and FGF receptor by immunohistochemistry in 32 human pancreatic ductal adenocarcinomas. Mild to marked basic FGF immunoreactivity was noted in 19 (59.4%) of the 32 tumours examined, and 30 (93.3%) of the tumours exhibited a cytoplasmic staining pattern against FGF receptor. The tumours were divided into two groups according to the proportion of positively stained tumour cells: A low expression group (positive cells ≪ 25%) and a high expression group (positive cells > or = 25%). No statistically significant difference in tumour size, differentiation, metastases or stage was found between the low and high basic FGF expression groups. However, a significant correlation was found between FGF receptor expression level and the presence of retroperitoneal invasion, lymph node metastasis, and tumour stage. In addition, low FGF receptor expression was significantly associated with a longer post-operative survival as compared with high FGF receptor expression, whereas there was no significant difference in post-operative survival between the low and high basic FGF expression groups. Increased expression of FGF receptor is correlated with the extent of malignancy and post-operative survival in human pancreatic ductal adenocarcinomas. Thus, overexpression of FGF receptor may prove to be a more useful prognostic marker than basic FGF expression level in pancreatic cancer patients. © 1995 Stockton Press. All rights reserved. | |||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | Embargo Period 12 months | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 権利情報 | Copyright © 1995 Stockton Press. | |||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
