| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-03-23 |
| タイトル |
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タイトル |
Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00050643 |
|
ID登録タイプ |
JaLC |
| 著者 |
Nakanishi, Chiaki
Nagaya, Noritoshi
Ohnishi, Shunsuke
Yamahara, Kenichi
Takabatake, Shu
Konno, Tetsuo
Hayashi, Kenshi
Kawashiri, Masa-aki
Tsubokawa, Toshinari
Yamagishi, Masakazu
|
| 著者別表示 |
中西, 千明
今野, 哲雄
林, 研至
川尻, 剛照
山岸, 正和
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
Circulation Journal
巻 75,
号 9,
p. 2260-2268,
発行日 2011-09
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-9843 |
| NCID |
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識別子タイプ |
NCID |
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関連識別子 |
BA81861067 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1253/circj.CJ-11-0246 |
| 出版者 |
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出版者 |
Japanese Circulation Society = 日本循環器学会 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Mesenchymal stem cells (MSC) are multipotent and reside in bone marrow (BM), adipose tissue and many other tissues. However, the molecular foundations underlying the differences in proliferation, differentiation potential and paracrine effects between adipose tissue-derived MSC (ASC) and BM-derived MSC (BM-MSC) are not well-known. Therefore, we investigated differences in the gene and secretory protein expressions of the 2 types of MSC. Methods and Results: ASC and BM-MSC were obtained from subcutaneous adipose tissue and BM of adult Lewis rats. ASC proliferated as rapidly as BM-MSC, and had expanded 200-fold in approximately 2 weeks. On microarray analysis of 31,099 genes, 571 (1.8%) were more highly (>3-fold) expressed in ASC, and a number of these genes were associated with mitosis and immune response. On the other hand, 571 genes (1.8%) were more highly expressed in BM-MSC, and some of these genes were associated with organ development and morphogenesis. In secretory protein analysis, ASC secreted significantly larger amounts of growth factor and inflammatory cytokines, such as vascular endothelial growth factor, hepatocyte growth factor and interleukin 6, whereas BM-MSC secreted significantly larger amounts of stromal-derived factor-1α. Conclusions: There are significant differences between ASC and BM-MSC in the cytokine secretome, which may provide clues to the molecule mechanisms associated with tissue regeneration and alternative cell sources. |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
出版者照会後に全文公開 |
| 権利 |
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|
権利情報 |
Copyright © Japanese Circulation Society 日本循環器学会 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.j-circ.or.jp/ |
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関連名称 |
http://www.j-circ.or.jp/ |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jstage.jst.go.jp/browse/circj/-char/en |
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関連名称 |
https://www.jstage.jst.go.jp/browse/circj/-char/en |
ME-PR-YAMAGISHI-M-2260.pdf (2.3 MB)
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