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肺癌におけるcMetによるtopoisomeraseIの活性制御の解析
https://doi.org/10.24517/00050947
https://doi.org/10.24517/0005094755ef92e0-433c-43db-a75b-89769d448d1e
名前 / ファイル | ライセンス | アクション |
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ME-PR-KASAHARA-K-kaken 2017-5p.pdf (764.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-06-04 | |||||
タイトル | ||||||
タイトル | 肺癌におけるcMetによるtopoisomeraseIの活性制御の解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Regulation of Topisomerase I activity by cMet in lung cancer | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050947 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Kasahara, Kazuo
× Kasahara, Kazuo |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2016 Fiscal Year Final Research Report 巻 2014-04-01 - 2017-03-31, p. 5p., 発行日 2017-06-12 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 肺癌における増殖因子受容体cMetと核内DNA複製酵素のTopoIの関連を検討した。10種類の培養細胞を用いてcMetを検討したところ5細胞株でcMet高発現、リン酸化亢進を認めた。核内のTopoI発現、活性はcMet高発現細胞で高く活性も亢進しており、TopoI阻害剤の感受性と関連していた。cMet阻害で、 TopoIも低下した。下流シグランルの検討では、TopoI発現に関連する29の候補遺伝子を同定した。臨床検体を用いた解析で、cMetは37.7%、TopoIは51.3%で陽性を指名し、有意な相関を認めた。cMetがTopoI発現を調節している可能性が示唆され、治療戦略確立が期待される。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the relationship between cMet and Topoisomerase I lung cancer. Protein expression and phosphorylation of cMet using 10 lung cancer cell lines revealed high expression and hyperphosphorylation in 5 cell line.Expression and activity of Topo I were higher in cMet overexpressing cells and were related to the sensitivity of Topo I inhibitors. Inhibition of cMet by Met inhibitor also decreased Topo I. Upon examination of the downstream signaling, 29 candidate genes associated with Topo I expression were identified by cMet stimulation and suppression. In analysis using clinical donation, cMet nominated positive with 37.7% and TopoI at 51.3%, showing a significant correlation. This study suggests that cMet may regulate the expression of Topo I and we believe that it will bring important findings to establish future treatment strategies. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:26430159, 研究期間(年度):2014-04-01 - 2017-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:「肺癌におけるcMetによるtopoisomeraseIの活性制御の解析」研究成果報告書 課題番号26430159 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430159/26430159seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=30272967 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=30272967 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430159/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430159/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430159/26430159seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430159/26430159seika/ |