| Item type |
学術雑誌論文 / Journal Article_04(1) |
| 公開日 |
2018-11-09 |
| タイトル |
|
|
タイトル |
Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00052742 |
|
ID登録タイプ |
JaLC |
| 著者 |
Sawada, Takeshi
Yamamoto, Eiichiro
Yamano, Hiro-o
Nojima, Masanori
Harada, Taku
Maruyama, Reo
Ashida, Masami
Aoki, Hironori
Matsushita, Hiro-o
Yoshikawa, Kenjiro
Harada, Eiji
Tanaka, Yoshihito
Wakita, Shigenori
Niinuma, Takeshi
Kai, Masahiro
Eizuka, Makoto
Sugai, Tamotsu
Suzuki, Hiromu
|
| 著者別表示 |
澤田, 武
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健学総合研究科先進的地域医療研究講座 = Department of Advanced Research in Community Medicine |
| 書誌情報 |
Oncotarget
巻 7,
号 23,
p. 35106-35118,
発行日 2016
|
| ISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1949-2553 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.18632/oncotarget.9044 |
| 出版者 |
|
|
出版者 |
Impact Journals |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
To clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions from 94 individuals. We then compared those results with the lesions’ clinicopathological features, especially colorectal subsites. The lesions included hyperplastic polyps (n = 16), traditional serrated adenomas (TSAs) (n = 15), TSAs with sessile serrated adenomas (SSAs) (n = 6), SSAs (n = 49) and SSAs with dysplasia (n = 16). The prevalence of lesions exhibiting the CpG island methylator phenotype (CIMP) was lower in the sigmoid colon and rectum than in other bowel subsites, including the cecum, ascending, transverse and descending colon. In addition, several cancer-associated genes showed higher methylation levels within lesions in the proximal to sigmoid colon than in the sigmoid colon and rectum. These results indicate that the methylation status of lesions with BRAF mutation is strongly associated with their location, histological findings and neoplastic pathways. By contrast, no difference in aberrant DNA methylation was observed in normal-appearing background colonic mucosa along the bowel subsites, which may indicate the absence of an epigenetic field defect. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/27145369 |
|
|
関連名称 |
https://www.ncbi.nlm.nih.gov/pubmed/27145369 |
| 関連URI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.18632/oncotarget.9044 |
|
|
関連名称 |
https://doi.org/10.18632/oncotarget.9044 |
ME-PR-SAWADA-T-35106.pdf (4.8 MB)
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