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Insulin-Like Growth Factor (Igf) - Ii and Igf-Binding Protein in Human Spinal Fluid
https://doi.org/10.24517/00052949
https://doi.org/10.24517/00052949ebf9872c-6583-4312-b959-ac3e67a29831
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-IGARASHI-N-79.pdf (5.0 MB)
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| Item type | 学術雑誌論文 / Journal Article_04(1) | |||||||||||
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| 公開日 | 2018-12-20 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Insulin-Like Growth Factor (Igf) - Ii and Igf-Binding Protein in Human Spinal Fluid | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| ID登録 | ||||||||||||
| ID登録 | 10.24517/00052949 | |||||||||||
| ID登録タイプ | JaLC | |||||||||||
| 著者 |
Igarashi, Noboru
× Igarashi, Noboru
× Takeya, Ryouhei
× Sato, Tamotsu
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| 著者別表示 |
五十嵐, 登
× 五十嵐, 登
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| 書誌情報 |
Clinical Pediatric Endocrinology 巻 2, p. 79-84, 発行日 1993 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0918-5739 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1297/cpe.2.Supple2_79 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 日本小児内分泌学会 = The Japanese Society for Pediatric Endocrinology | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024290405&doi=10.1297%2fcpe.2.Supple2_79&partnerID=40&md5=12626aca76eb2a4e78f5240390705369 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Insulin-like growth factor-II (IGF-II) and its specific receptor are present in the central nervous system (CNS) of experimental animal models, where this peptide has unique roles in neuronal growth and differentiation. IGF-II in the cerebrospinal fluid (CSF), as well as in plasma, is bound to specific binding protein (IGFBP). In this study we examined CSF IGF-II levels and IGFBP patterns in children with various physiological and pathological states. IGF-II, dissociated from IGFBP by acid gel chromatography, was measured by RIA, and IGFBP analyzed by western-ligand blotting. CSF IGF- II levels were 16.7±4.9 ng/ml in control subjects and there were no age-related variations. In some cases with CNS tumor, hydrocephalus and inflammatory conditions, their CSF IGF-II levels were increased. CSF IGFBP mainly consisted of 34kd, 31kd and 24kd protein. In contrast to serum IGFBP, CSF IGFBP patterns were almost unaffected by age, and were increased in some CNS inflammatoryconditions. Although the specific role of IGF-II in the human CNS remains to be defined, our results suggest that the regulatory mechanisms for the IGF-II /IGFBP system are present in the human CNS as well as in animal models. | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | rights(c) 日本小児内分泌学会 The Japanese Society for Pediatric Endocrinology | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 関連URI | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/cpe/-char/ja | |||||||||||
| 関連名称 | https://www.jstage.jst.go.jp/browse/cpe/-char/ja | |||||||||||
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| 識別子タイプ | URI | |||||||||||
| 関連識別子 | http://jspe.umin.jp/ | |||||||||||
| 関連名称 | http://jspe.umin.jp/ | |||||||||||
| 関連URI | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://ci.nii.ac.jp/naid/130004237954 | |||||||||||
