| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-04-01 |
| タイトル |
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|
タイトル |
Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00053792 |
|
ID登録タイプ |
JaLC |
| 著者 |
Aono, Daisuke
Oka, Rie
Kometani, Mitsuhiro
Takeda, Yoshimichi
Karashima, Shigehiro
Yoshimura, Kenichi
Takeda, Yoshiyu
Yoneda, Takashi
|
| 著者別表示 |
青野, 大輔
大家, 理恵
米谷, 充弘
武田, 仁裕
唐島, 成宙
吉村, 健一
武田, 仁勇
米田, 隆
|
| 提供者所属 |
|
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学附属病院代謝内科 |
| 書誌情報 |
Journal of Diabetes Research
巻 2018,
p. 5107589-9 pages,
発行日 2018-05-22
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2314-6745 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1155/2018/5107589 |
| 出版者 |
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出版者 |
Hindawi Publishing Corporation |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Aim. To characterize subjects with a nonpositive insulinogenic index and longitudinally observe changes in their glucose tolerance. Subjects and Methods. A historical cohort study was conducted using data from the medical checkups of public school workers. Indices of insulin secretion and insulin sensitivity derived from oral glucose tolerance test (OGTT) and the incidences of diabetes and impaired glucose tolerance (IGT) were compared among subgroups of subjects with different insulinogenic index (change in insulin/change in glucose over the first 30 min on the OGTT). Results. Of the 1464 nondiabetic subjects at baseline, 72 (4.9%) subjects had a nonpositive insulinogenic index: 42 of those subjects had a nonpositive glucose response (ΔGlu0–30 ≤ 0) and 30 had a nonpositive insulin response (ΔIns0–30 ≤ 0). Compared with subjects who had normal glucose tolerance (NGT) with insulinogenic index ≥ 0.4, subjects with a nonpositive glucose response had a higher first-phase Stumvoll and lower incidences of diabetes and IGT based on a log-rank test (), whereas subjects with a nonpositive insulin response had lower indices of insulin secretion and a higher incidence of diabetes (). Conclusions. These results demonstrate that in the first 30 min on the OGTT, subjects with a nonpositive insulinogenic index due to a nonpositive glucose response (ΔGlu0–30 ≤ 0) had a lower risk for future diabetes and that subjects with nonpositive insulin response (ΔIns0–30 ≤ 0) had a higher risk for future one. |
| 権利 |
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|
権利情報 |
Copyright © 2018 Daisuke Aono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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|
識別子タイプ |
URI |
|
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関連識別子 |
https://www.hindawi.com/journals/jdr/2018/5107589/ |
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関連名称 |
https://www.hindawi.com/journals/jdr/2018/5107589/ |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/29765987 |
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|
関連名称 |
https://www.ncbi.nlm.nih.gov/pubmed/29765987 |
HO-PR-OKA-R-5107589.pdf (815.0 kB)
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