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  1. C. 医薬保健学域; 医学類・薬学類・医薬科学類・保健学類
  2. c 10. 学術雑誌掲載論文(医・保健)
  3. 1. 査読済論文(医学・保健)

Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID).

https://doi.org/10.24517/00053812
https://doi.org/10.24517/00053812
fe3e0adf-66f7-46f0-83ed-7f5c48dde677
名前 / ファイル ライセンス アクション
ME-PR-KITAMURA-K-31715-27.pdf ME-PR-KITAMURA-K-31715-27.pdf (2.8 MB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-04-05
タイトル
タイトル Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID).
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
ID登録
ID登録 10.24517/00053812
ID登録タイプ JaLC
著者 Watashi, Koichi

× Watashi, Koichi

WEKO 84202

Watashi, Koichi

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Liang, Guoxin

× Liang, Guoxin

WEKO 84203

Liang, Guoxin

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Iwamoto, Masashi

× Iwamoto, Masashi

WEKO 84204

Iwamoto, Masashi

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Marusawa, Hiroyuki

× Marusawa, Hiroyuki

WEKO 84205

Marusawa, Hiroyuki

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Uchida, Nanako

× Uchida, Nanako

WEKO 84206

Uchida, Nanako

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Daito, Takuji

× Daito, Takuji

WEKO 84207

Daito, Takuji

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Kitamura, Kouichi

× Kitamura, Kouichi

WEKO 84208
e-Rad 70378892

Kitamura, Kouichi

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Muramatsu, Masamichi

× Muramatsu, Masamichi

WEKO 84209
e-Rad 20359813

Muramatsu, Masamichi

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Ohashi, Hirofumi

× Ohashi, Hirofumi

WEKO 84210

Ohashi, Hirofumi

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Kiyohara, Tomoko

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WEKO 84211

Kiyohara, Tomoko

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Suzuki, Ryosuke

× Suzuki, Ryosuke

WEKO 84212

Suzuki, Ryosuke

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Li, Jisu

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WEKO 84213

Li, Jisu

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Tong, Shuping

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WEKO 84214

Tong, Shuping

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Tanaka, Yasuhito

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WEKO 84215

Tanaka, Yasuhito

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Murata, Kazumoto

× Murata, Kazumoto

WEKO 84216

Murata, Kazumoto

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Aizaki, Hideki

× Aizaki, Hideki

WEKO 84217

Aizaki, Hideki

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Wakita, Takaji

× Wakita, Takaji

WEKO 84218

Wakita, Takaji

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著者別表示 喜多村, 晃一

× 喜多村, 晃一

喜多村, 晃一

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村松, 正道

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村松, 正道

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提供者所属
内容記述タイプ Other
内容記述 金沢大学医薬保健研究域医学系
書誌情報 Journal of Biological Chemistry

巻 288, 号 44, p. 31715-31727, 発行日 2013-11-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0021-9258
NCID
収録物識別子タイプ NCID
収録物識別子 AA00251083
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1074/jbc.M113.501122
出版者
出版者 American Society for Biochemistry and Molecular Biology Inc.
抄録
内容記述タイプ Abstract
内容記述 Virus infection is restricted by intracellular immune responses in host cells, and this is typically modulated by stimulation of cytokines. The cytokines and host factors that determine the host cell restriction against hepatitis B virus (HBV) infection are not well understood. We screened 36 cytokines and chemokines to determine which were able to reduce the susceptibility of HepaRG cells to HBV infection. Here, we found that pretreatment with IL-1β and TNFα remarkably reduced the host cell susceptibility to HBV infection. This effect was mediated by activation of the NF-κB signaling pathway. A cytidine deaminase, activation-induced cytidine deaminase (AID), was up-regulated by both IL-1β and TNFα in a variety of hepatocyte cell lines and primary human hepatocytes. Another deaminase APOBEC3G was not induced by these proinflammatory cytokines. Knockdown of AID expression impaired the anti-HBV effect of IL-1β, and overexpression of AID antagonized HBV infection, suggesting that AID was one of the responsible factors for the anti-HBV activity of IL-1/TNFα. Although AID induced hypermutation of HBV DNA, this activity was dispensable for the anti-HBV activity. The antiviral effect of IL-1/TNFα was also observed on different HBV genotypes but not on hepatitis C virus. These results demonstrate that proinflammatory cytokines IL-1/TNFα trigger a novel antiviral mechanism involving AID to regulate host cell permissiveness to HBV infection.
権利
権利情報 Copyright © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連URI
識別子タイプ URI
関連識別子 http://www.jbc.org/content/288/44/31715
関連名称 http://www.jbc.org/content/288/44/31715
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