| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-04-05 |
| タイトル |
|
|
タイトル |
Role of Activation-Induced Cytidine Deaminase in the Development of Oral Squamous Cell Carcinoma |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00053815 |
|
ID登録タイプ |
JaLC |
| 著者 |
Nakanishi, Yosuke
Kondo, Satoru
Wakisaka, Naohiro
Tsuji, Akira
Endo, Kazuhira
Murono, Shigeyuki
Ito, Makoto
Kitamura, Kouichi
Muramatsu, Masamichi
Yoshizaki, Tomokazu
|
| 著者別表示 |
近藤, 悟
脇坂, 尚宏
辻, 亮
遠藤, 一平
室野, 重之
喜多村, 晃一
村松, 正道
吉崎, 智一
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
PLoS ONE
巻 8,
号 4,
p. e62066,
発行日 2013-04-25
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1932-6203 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1371/journal.pone.0062066 |
| 出版者 |
|
|
出版者 |
Public Library of Science |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose:In humans, activation-induced cytidine deaminase (AID) expression results due to inflammation and this deaminase activity is also involved in carcinogenesis. The aim of this study is to investigate the correlation between AID expression and the clinical classification of oral cancer tissues.Experimental Design:The current study investigated the correlation between AID expression and the clinical classification of oral cancer tissues from 27 patients who underwent surgical resection using immunohistochemistry. Specific AID expression and its induction by cytokine stimulation were investigated in cultured HSC oral cancer cell lines by reverse transcriptase PCR.Results:AID expression was detected in 10 of 27 specimens (37.0%). AID expression was more frequently detected in early-stage cancer, especially in early stage T, than in late-stage cancer (T1/T2 vs. T3/4; P = 0.0493, N0 vs. N1/2/3; P = 0.0793). HSC-2, a nonmetastatic oral cancer cell line, abundantly expressed endogenous AID, whereas no such expression was observed in HSC-3, a metastatic oral cancer cell line. Moreover, AID expression was substantially induced in HSC-2 cells by stimulation of an inflammation-related cytokine, TNF-α.Conclusions:Aberrant AID expression in the oral epithelium would contribute to the initiation of oral squamous cell carcinoma. Avoiding persistent AID inducible condition such as frequent cleaning of oral cavity would play an important role for the prevention of developing oral cancer. © 2013 Nakanishi et al. |
| 権利 |
|
|
権利情報 |
Copyright © 2013 Nakanishi et al. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062066 |
|
|
関連名称 |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062066 |
ME-PR-KITAMURA-K-0062066.pdf (5.4 MB)
.png)
