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加速器生産α線放出核種の内用放射療法への適応
https://doi.org/10.24517/00056765
https://doi.org/10.24517/00056765968a702e-9992-4dd4-b34e-ebe1fa136bad
名前 / ファイル | ライセンス | アクション |
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ME-PR-WASHIYAMA-K-kaken 2011-4p.pdf (235.9 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-02-03 | |||||
タイトル | ||||||
タイトル | 加速器生産α線放出核種の内用放射療法への適応 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | An application of accelerator produced alpha-emitting radionuclide for radionuclide therapy | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00056765 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Washiyama, Kohshin
× Washiyama, Kohshin |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域保健学系 | |||||
書誌情報 |
平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書 en : 2010 Fiscal Year Final Research Report 巻 2008-2010, p. 4p., 発行日 2011-05-19 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本研究では、加速器を用いた核反応で製造した^<230>Paを利用して、^<230>U/^<226>Thジェネレータの製造法を検討した。また、ミルキングした^<226>Thで標識した^<226>Th-EDTMPの骨集積に関する検討を行った。その結果、比較的簡単な化学分離で^<230>U/^<226>Thジェネレータを製造することに成功し、さらにミルキングした^<226>Thの標識化合物^<226>Th-EDTMPをマウスに尾静脈投与し、^<226>Th-EDTMPの骨への集積を確認した。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Targeted alpha therapy (TAT) has been applied for cancer therapy and many clinical studies have been performed. Uranium-230 is a promising cyclotron produced alpha-emitting radionuclide for TAT. According to the reaction ^<232>Th(p, 3n)^<230>Pa and following the β- decay of ^<230>Pa, ^<230>U can be produced within the irradiated target. The daughter of ^<230>U, ^<226>Th (T_<1/2>=31m) provides a rapid cascade of 4 alpha particles with a 27.7MeV of total energy. In this study, we investigated the availability of production and radiochemical separation of ^<230>U and its daughters. Protactinium-230 was produced by irradiation of ^<232>ThO_2 target. After irradiation, the target was separated and ^<230>U/^<226>Th generator was constructed. Eluted ^<226>Th from generator was radiolabeled with bone seeking chelate, EDTMP and injected into mice for biodistribution evaluation. Most of all radioactivity were retained on bone. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「加速器生産α線放出核種の内用放射療法への適応」課題番号20790886 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790886/20790886seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=80313675 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=80313675 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790886/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790886/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790886/20790886seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790886/20790886seika/ |