| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2020-07-31 |
| タイトル |
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タイトル |
Resistance of KIR ligand-missing leukocytes to natural killer cells in vivo in patients with acquired aplastic anemia |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00058826 |
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ID登録タイプ |
JaLC |
| 著者 |
Nguyen Thi, Mai Anh
Hosokawa, Kohei
Yoroidaka, Takeshi
Maruyama, Hiroyuki
Espinoza, J. Luis
Elbadry, Mahmoud I.
Md, Mohiuddin
Tanabe, Mikoto
Katagiri, Takamasa
Nakagawa, Noriharu
Arima, Nobuyoshi
Kashiwase, Koichi
Saji, Hiroh
Ogawa, Seishi
Nakao, Shinji
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| 著者別表示 |
細川, 晃平
片桐, 孝和
中尾, 眞二
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| 提供者所属 |
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内容記述タイプ |
Other |
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内容記述 |
金沢大学医薬保健研究域医学系 Graduate School of Medical Sciences |
| 書誌情報 |
ImmunoHorizons
巻 4,
号 7,
p. 430-441,
発行日 2020-07-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2573-7732 |
| 出版者 |
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出版者 |
The American Association of Immunologists |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The loss of killer cell immunoglobulin-like receptor-ligands (KIR-Ls) due to the copy number neutral loss of heterozygosity of chromosome 6p (6pLOH) in leukocytes of patients with acquired aplastic anemia (AA) may alter the susceptibility of the affected leukocytes to NK cell killing in vivo. We studied 408 AA patients, including 261 who were heterozygous for KIR-Ls, namely C1/C2 or Bw6/Bw4, for the presence of KIR-L-missing (KIR-L[-]) leukocytes. KIR-L(-) leukocytes were found in 14 (5.4%, C1, n= 4, C2, n=3, and Bw4, n= 7) of the 261 patients, in whom corresponding KIR(+) licensed NK cells were detected. The incidence of 6pLOH in the 261 patients (18.0%) was comparable to that in 147 patients (13.6%) who were homozygous for KIR-L genes. The percentages of HLA-lacking granulocytes (0.8-50.3%, median 15.2%) in the total granulocytes of the patients with KIR-L(-) cells were significantly lower than those (1.2-99.4%, median 55.4%) in patients without KIR-L(-) cells. KIR2DS1 and KIR3DS1 were only possessed by three of the 14 patients, two of whom had C2/C2 leukocytes after losing C1 alleles. The expression of the KIR3DS1 ligand HLA-F was selectively lost on KIR-L(-) primitive hematopoietic stem cells (HSCs) derived from 6pLOH(+) iPS cells in one of the KIR3DS1(+) patients. These findings suggest that human NK cells are able to suppress the expansion of KIR-L(-) leukocytes but are unable to eliminate them partly due to the lack of activating KIRs on NK cells and the low HLA-F expression level on HSCs in AA patients. |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Embargo Period 6 months |
| 権利 |
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権利情報 |
Copyright© 2020 by The American Association of Immunologists |
| 著者版フラグ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.immunohorizons.org/ |
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関連名称 |
https://www.immunohorizons.org/ |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.aai.org/ |
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関連名称 |
https://www.aai.org/ |
ME-PR-NGUYEN THI MAI ANH-430.pdf (351.3 kB)
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