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Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia
https://doi.org/10.24517/00062706
https://doi.org/10.24517/000627064123b5e3-e952-4e92-b392-4ad743ca2452
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-MAEDA-D-32.pdf (2.4 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2021-06-28 | |||||||
| タイトル | ||||||||
| タイトル | Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00062706 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Baba, Satoshi
× Baba, Satoshi× Taguchi, Ayumi× Kawata, Akira× Hara, Konan× Eguchi, Satoko× Mori, Mayuyo× Adachi, Katsuyuki× Mori, Seiichiro× Iwata, Takashi× Mitsuhashi, Akira× Maeda, Daichi× Komatsu, Atsushi× Nagamatsu, Takeshi× Oda, Katsutoshi× Kukimoto, Iwao× Osuga, Yutaka× Fujii, Tomoyuki× Kawana, Kei |
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| 著者別表示 |
前田, 大地
× 前田, 大地
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||
| 書誌情報 |
Virology Journal 巻 17, 号 1, p. 32, 発行日 2020-03-06 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1743-422X | |||||||
| NCID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA12048316 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1186/s12985-020-01306-0 | |||||||
| 出版者 | ||||||||
| 出版者 | BioMed Central Ltd. | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background: Human papillomavirus (HPV) infection is a primary cause of cervical cancer. Although epidemiologic study revealed that carcinogenic risk differs according to HPV genotypes, the expression patterns of HPV-derived transcripts and their dependence on HPV genotypes have not yet been fully elucidated. Methods: In this study, 382 patients with abnormal cervical cytology were enrolled to assess the associations between HPV-derived transcripts and cervical intraepithelial neoplasia (CIN) grades and/or HPV genotypes. Specifically, four HPV-derived transcripts, namely, oncogenes E6 and E6*, E1^E4, and viral capsid protein L1 in four major HPV genotypes-HPV 16, 18, 52, and 58-were investigated. Results: The detection rate of E6/E6*increased with CIN progression, whereas there was no significant change in the detection rate of E1^E4 or L1 among CIN grades. In addition, we found that L1 gene expression was HPV type-dependent. Almost all HPV 52-positive specimens, approximately 50% of HPV 58-positive specimens, around 33% of HPV 16-positive specimens, and only one HPV18-positive specimen expressed L1. Conclusions: We demonstrated that HPV-derived transcripts are HPV genotype-dependent. Especially, expression patterns of L1 gene expression might reflect HPV genotype-dependent patterns of carcinogenesis. © 2020 The Author(s). | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © BioMed Central Ltd. | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.virologyj.com/ | |||||||
| 関連名称 | http://www.virologyj.com/ | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01306-0 | |||||||
| 関連名称 | https://virologyj.biomedcentral.com/articles/10.1186/s12985-020-01306-0 | |||||||
