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Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals
https://doi.org/10.24517/00062819
https://doi.org/10.24517/000628198b986f1b-d94c-4f9d-b169-4df2a13178af
| 名前 / ファイル | ライセンス | アクション |
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FR-PR-HIGUCHI-A-36903.pdf (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2021-07-05 | |||||||
| タイトル | ||||||||
| タイトル | Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00062819 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Higuchi, Akihiro
× Higuchi, Akihiro× Inoue, Hiroyoshi× Kaneko, Yoshio× Oonishi, Erina× Tsubota, Kazuo |
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| 著者別表示 |
樋口, 明弘
× 樋口, 明弘
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学先端科学・社会共創推進機構 | |||||||
| 書誌情報 |
Scientific Reports 巻 6, p. 36903, 発行日 2016-11-11 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 2045-2322 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1038/srep36903 | |||||||
| 出版者 | ||||||||
| 出版者 | Nature Research | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The ocular surface is strongly affected by oxidative stress, which causes many ocular diseases including dry eye. Previously, we showed that selenium compounds, e.g., selenoprotein P and Se-lactoferrin, were candidates for treatment of dry eye. This paper shows the efficacy of Se-lactoferrin for the treatment of dry eye compared with Diquas as a control drug using two dry eye models and incorporation of lactoferrin into corneal epithelial cells via lactoferrin receptors. We show the efficacy of Se-lactoferrin eye drops in the tobacco smoke exposure rat dry eye model and short-term rabbit dry eye model, although Diquas eye drops were only effective in the short-term rabbit dry eye model. These results indicate that Se-lactoferrin was useful in the oxidative stress-causing dry eye model. Se-lactoferrin was taken into corneal epithelium cells via lactoferrin receptors. We identified LRP1 as the lactoferrin receptor in the corneal epithelium involved in lactoferrin uptake. Se-lactoferrin eye drops did not irritate the ocular surface of rabbits. Se-lactoferrin was an excellent candidate for treatment of dry eye, reducing oxidative stress by a novel mechanism. © 2016 The Author(s). | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Nature Research | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.nature.com/srep/index.html | |||||||
| 関連名称 | http://www.nature.com/srep/index.html | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.nature.com/articles/srep36903 | |||||||
| 関連名称 | https://www.nature.com/articles/srep36903 | |||||||
