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Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency
https://doi.org/10.24517/00062989
https://doi.org/10.24517/0006298985463124-3fcb-4336-adb6-8bda6905dfff
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-NAITO-H-11137.pdf (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2021-07-05 | |||||||||
| タイトル | ||||||||||
| タイトル | Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00062989 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Yoshida, Mari
× Yoshida, Mari× Ishioka, Yukichi× Ozawa, Takamasa× Okuyama, Hirohisa× Iguchi, Motofumi× Ota, Takeshi× Ito, Takaomi× Nagira, Morio× Morita, Atsushi× Tanaka, Hidekazu× Naito, Hisamichi× Kidoya, Hiroyasu× Takakura, Nobuyuki |
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| 著者別表示 |
内藤, 尚道
× 内藤, 尚道
× 高倉, 伸幸
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||||
| 書誌情報 |
Scientific Reports 巻 7, 号 1, p. 11137, 発行日 2017-09-11 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 2045-2322 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1038/s41598-017-11605-2 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Nature Research / Nature Publishing Group | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Partner of sld five 1 (PSF1) is an evolutionary conserved DNA replication factor involved in DNA replication in lower species, which is strongly expressed in normal stem cell populations and progenitor cell populations. Recently, we have investigated PSF1 functions in cancer cells and found that PSF1 plays a significant role in tumour growth. These findings provide initial evidence for the potential of PSF1 as a therapeutic target. Here, we reveal that PSF1 contains an immunogenic epitope suitable for an antitumour vaccine. We analysed PSF1 peptides eluted from affinity-purified human leukocyte antigen (HLA) by mass spectrometry and identified PSF179-87 peptide (YLYDRLLRI) that has the highest prediction score using an in silico algorithm. PSF179-87 peptide induced PSF1-specific cytotoxic T lymphocyte responses such as the production of interferon-γ and cytotoxicity. Because PSF1 is expressed in cancer cell populations and highly expressed in cancer stem cell populations, these data suggest that vaccination with PSF179-87 peptide may be a novel therapeutic strategy for cancer treatment. © 2017 The Author(s). | |||||||||
| 権利 | ||||||||||
| 権利情報 | copyright © Nature Research | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.nature.com/srep/index.html | |||||||||
| 関連名称 | http://www.nature.com/srep/index.html | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.nature.com/articles/s41598-017-11605-2 | |||||||||
| 関連名称 | https://www.nature.com/articles/s41598-017-11605-2 | |||||||||
