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Oropharyngeal dysphagia in dermatomyositis: Associations with clinical and laboratory features including autoantibodies
https://doi.org/10.24517/00064883
https://doi.org/10.24517/00064883385e6983-ef6d-4e60-870d-ca030798a773
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-SOMEYA-F-e0154746.pdf (350.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2022-01-21 | |||||
| タイトル | ||||||
| タイトル | Oropharyngeal dysphagia in dermatomyositis: Associations with clinical and laboratory features including autoantibodies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| ID登録 | ||||||
| ID登録 | 10.24517/00064883 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
Mugii, Naoki
× Mugii, Naoki× Hasegawa, Minoru× Matsushita, Takashi× Hamaguchi, Yasuhito× Oohata, Sacihe× Okita, Hirokazu× Yahata, Tetsutaro× Someya, Fujiko× Inoue, Katsumi× Murono, Shigeyuki× Fujimoto, Manabu× Takehara, Kazuhiko |
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| 著者別名 |
麦井, 直樹
× 麦井, 直樹× 長谷川, 稔× 松下, 貴史× 濱口, 儒人× 八幡, 徹太郎× 染矢, 富士子× 室野, 重之× 藤本, 学× 竹原, 和彦 |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学医薬保健研究域保健学系 | |||||
| 書誌情報 |
PLoS ONE 巻 11, 号 5, p. e0154746, 発行日 2016-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1932-6203 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1371/journal.pone.0154746 | |||||
| 出版者 | ||||||
| 出版者 | Public Library of Science | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Dysphagia develops with low frequency in patients with dermatomyositis. Our objective was to determine the clinical and laboratory features that can estimate the development of dysphagia in dermatomyositis. Methods: This study included 92 Japanese patients with adult-onset dermatomyositis. The associations between dysphagia and clinical and laboratory features including disease-specific autoantibodies determined by immunoprecipitation assays were analyzed. Results: Videofluoroscopy swallow study (VFSS) was performed for all patients with clinical dysphagia (n = 13, 14.1%) but not for patients without clinical dysphagia. Typical findings of dysphagia (pharyngeal pooling, n = 11 and/or nasal regurgitation, n = 4) was detected by VFSS in all patients with clinical dysphagia. Eleven patients with dysphagia (84.6%) had anti-transcription intermediary factor 1γ (TIF-1γ) antibody. By univariate analysis, the average age and the male to female ratio, internal malignancy, and anti-TIF-1γ antibody were significantly higher and the frequency of interstitial lung diseases and manual muscle testing (MMT) scores of sternomastoid and dertoid muscles were significantly lower in patients with dysphagia than in patients without dysphagia. Among patients with anti-TIF-1γ antibody, the mean age, the ratios of male to female and internal malignancy were significantly higher and mean MMT scores of sternomastoid muscle were significantly lower in patients with dysphagia compared with patients without dysphagia. By multivariable analysis, the risk of dysphagia was strongly associated with the existence of internal malignancy and ant-TIF-1γ antibody and was also associated with reduced scores of manual muscle test of sternomastoid muscle. Dysphagia was markedly improved after the treatment against myositis in all 13 patients. Conclusion: These findings indicate that dysphagia can develop frequently in patients with internal malignancy, anti-TIF-1γ antibody, or severe muscle weakness of sternomastoid muscle. © 2016 Mugii et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © Public Library of Science | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.plosone.org/ | |||||
| 関連名称 | http://www.plosone.org/ | |||||
