| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-03-11 |
| タイトル |
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タイトル |
Postconditioning accelerates myocardial inflammatory resolution demonstrated by 14C-methionine imaging and attenuates ventricular remodeling after ischemia and reperfusion |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00065231 |
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ID登録タイプ |
JaLC |
| 著者 |
Taki, Junichi
Inaki, Anri
Wakabayashi, Hiroshi
Matsunari, Ichiro
Imanaka-Yoshida, Kyoko
Ogawa, Kazuma
Hiroe, Michiaki
Shiba, Kazuhiro
Kinuya, Seigo
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| 著者別表示 |
瀧, 淳一
稲木, 杏吏
若林, 大志
小川, 数馬
柴, 和弘
絹谷, 清剛
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| 提供者所属 |
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内容記述タイプ |
Other |
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内容記述 |
金沢大学疾患モデル総合研究センター |
| 書誌情報 |
Circulation Journal
巻 83,
号 12,
p. 2520-2526,
発行日 2019-11-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-9843 |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1347-4820 |
| NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11591968 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1253/circj.CJ-19-0462 |
| 出版者 |
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出版者 |
Japanese Circulation Society |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Methionine uptake after myocardial infarction has been proven to reflect myocardial inflammation. The effect of postconditioning on the post-infarction inflammatory process, however, remains to be elucidated. Methods and Results: In control (n=22) and postconditioning rats (n=23), the left coronary artery was occluded for 30min, followed by reperfusion for 1, 3, 7, and 14 days. Postconditioning was performed immediately following the reperfusion. 14C-methinine (0.74MBq) and 201Tl (14.8MBq) were injected 20 and 10min prior to sacrifice, respectively. One minute before sacrifice, 150–180MBq of 99mTc-MIBI was injected immediately following the re-occlusion of the left coronary artery to verify the area at risk, and left ventricular triple-tracer autoradiography was performed. To examine the ventricular remodeling, echocardiography was performed 2 months after reperfusion in both groups (n=6 each). In the control rats, the methionine uptake ratios on days 1, 3, 7, and 14 were 0.74±0.12, 1.85±0.16, 1.48±0.10, 1.25±0.04, respectively. With postconditioning, methionine uptake was similar on day 3 (1.90±0.21), but was lower on day 7 (1.23±0.22, P<0.05) and day 14 (1.08±0.09, P<0.005). Echocardiography revealed that postconditioning reduced the ventricular end-diastolic (0.97±0.16 to 0.78±0.12cm, P<0.05) and systolic (0.85±0.21 to 0.55±0.23cm, P<0.05) dimensions and improved ventricular percentage fractional shortening (12±6.2 to 29±12 %, P=0.01). Conclusions: 14C-methinine imaging revealed that postconditioning accelerated resolution of inflammation and attenuated ventricular remodeling. © 2019 Japanese Circulation Society. All rights reserved. |
| 権利 |
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権利情報 |
Copyright © Japanese Circulation Society 日本循環器学会 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.plosone.org/ |
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関連名称 |
http://www.plosone.org/ |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jstage.jst.go.jp/browse/circj/-char/ja/ |
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関連名称 |
https://www.jstage.jst.go.jp/browse/circj/-char/ja/ |
ME-PR-SHIBA-K-83-2520.pdf (782.2 kB)
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