Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2022-01-31 |
タイトル |
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タイトル |
Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
ID登録 |
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ID登録 |
10.24517/00065237 |
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ID登録タイプ |
JaLC |
著者 |
Lopatina, Olga
Yoshihara, Toru
Nishimura, Tomoko
Zhong, Jing
Akther, Shirin
Fakhrul, Azam A.K.M.
Liang, Mingkun
Higashida, Chiharu
Sumi, Kohei
Furuhara, Kazumi
Inahata, Yuki
Huang, Jina-Jung
Koizumi, Keita
Yokoyama, Shigeru
Tsuji, Takahiro
Petugina, Yulia
Sumarokov, Andrei
Salmina, Alla B.
Hashida, Koji
Kitao, Yasuko
Hori, Osamu
Asano, Masahide
Kitamura, Yoji
Kozaka, Takashi
Shiba, Kazuhiro
Zhong, Fangfang
Xie, Min-Jue
Sato, Makoto
Ishihara, Katsuhiro
Higashida, Haruhiro
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著者別表示 |
吉原, 亨
小泉, 恵太
横山, 茂
北尾, 康子
堀, 修
浅野, 雅秀
北村, 暘二
小阪, 孝史
柴, 和弘
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提供者所属 |
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内容記述タイプ |
Other |
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内容記述 |
金沢大学疾患モデル総合研究センター |
書誌情報 |
Frontiers in Behavioral Neuroscience
巻 8,
号 APR,
p. 133,
発行日 2014-04-22
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ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1662-5153 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.3389/fnbeh.2014.00133 |
出版者 |
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出版者 |
Frontiers Research Foundation |
抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositolanchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157-/-) male mice under less aging-related effects on behaviors. CD157-/- mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157-/- mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD. © 2014 Lopatina, Yoshihara, Nishimura, Zhong, Akther, Fakhrul, Liang, Higashida, Sumi, Furuhara, Inahata, Huang, Koizumi, Yokoyama, Tsuji, Petugina, Sumarokov, Salmina, Hashida, Kitao, Hori, Asano, Kitamura, Kozaka, Shiba, Zhong, Xie, Sato, Ishihara and Higashida. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
CC-BY 4.0 |
権利 |
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権利情報 |
This article was submitted to the journal Frontiers in Behavioral Neuroscience. |
権利 |
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権利情報 |
Copyright © 2014 Lopatina, Yoshihara, Nishimura, Zhong, Akther, Fakhrul, Liang, Higashida, Sumi, Furuhara, Inahata, Huang, Koizumi, Yokoyama, Tsuji, Petugina, Sumarokov, Salmina, Hashida, Kitao, Hori, Asano, Kitamura, Kozaka, Shiba, Zhong, Xie, Sato, Ishihara and Higashida. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://frontiersin.org/Behavioral_Neuroscience |
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関連名称 |
http://frontiersin.org/Behavioral_Neuroscience |
関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.frontiersin.org/articles/10.3389/fnbeh.2014.00133/full |
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関連名称 |
https://www.frontiersin.org/articles/10.3389/fnbeh.2014.00133/full |