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Correlation between apoptosis and left ventricular remodeling in subacute phase of myocardial ischemia and reperfusion
https://doi.org/10.24517/00065247
https://doi.org/10.24517/00065247a7a91523-690f-4dfc-a945-3cd113c356be
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-SHIBA-K-2015-5-72.pdf (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2022-01-31 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Correlation between apoptosis and left ventricular remodeling in subacute phase of myocardial ischemia and reperfusion | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| ID登録 | ||||||||||||||||
| ID登録 | 10.24517/00065247 | |||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||
| 著者 |
Wakabayashi, Hiroshi
× Wakabayashi, Hiroshi× Taki, Junichi× Inaki, Anri× Shiba, Kazuhiro× Matsunari, Ichir× Kinuya, Seigo |
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| 著者別表示 |
若林, 大志
× 若林, 大志
× 瀧, 淳一
× 稲木, 杏吏
× 柴, 和弘
× 絹谷, 清剛
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| 提供者所属 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | 金沢大学疾患モデル総合研究センター | |||||||||||||||
| 書誌情報 |
EJNMMI Research 巻 5, 号 1, p. 72, 発行日 2015-12-10 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 2191-219X | |||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1186/s13550-015-0152-9 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Springer Verlag | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Background To investigate whether an apoptotic process demonstrated by 99mTc-annexin-V (99mTc-AV) uptake correlates with left ventricular remodeling (LVR) after myocardial infarction, we assessed 99mTc-AV uptake in rat model of myocardial ischemia and reperfusion. Methods The left coronary artery (LCA) of 15 rats was occluded for 20 to 30 min, followed by reperfusion. After 2 weeks, 99mTc-AV was injected, and then 1 h later, 201Tl was injected after reocclusion of the LCA. Dual-tracer autoradiography was performed to assess 99mTc-AV uptake and the area at risk (AAR) by 201Tl defect. 99mTc-AV uptake ratio was calculated by dividing the count density of the AAR by that of the normally perfused area. In short-axis LV slices, LV cavity dilation index (DI) was calculated by dividing the area of LV cavity by that of the whole LV area. LV wall-thinning ratio (WTR) was calculated by dividing the LV wall thickness in the AAR by that of the normally perfused area. Results Significant 99mTc-AV uptake in the AAR was observed in 10 rats. DI was significantly higher in rats with positive 99mTc-AV uptake than in rats without uptake. WTR was smaller in rats with positive 99mTc-AV uptake than in rats without uptake. Conclusions The data suggest 99mTc-AV uptake in injured myocardium might correlate with LVR at 2 weeks after myocardial ischemia and reperfusion. |
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| 権利 | ||||||||||||||||
| 権利情報 | Copyright © 2015 Wakabayashi et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 関連URI | ||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||
| 関連識別子 | http://www.ejnmmires.com/ | |||||||||||||||
| 関連名称 | http://www.ejnmmires.com/ | |||||||||||||||
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| 識別子タイプ | URI | |||||||||||||||
| 関連識別子 | https://ejnmmires.springeropen.com/articles/10.1186/s13550-015-0152-9 | |||||||||||||||
| 関連名称 | https://ejnmmires.springeropen.com/articles/10.1186/s13550-015-0152-9 | |||||||||||||||
