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Sulfate activation in mitosomes plays an important role in the proliferation of entamoeba histolytica
https://doi.org/10.24517/00067082
https://doi.org/10.24517/0006708290f3e308-ccff-4a08-bae2-8387a33812aa
| 名前 / ファイル | ライセンス | アクション |
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PH-PR-FURUKAWA-A-5-1263.pdf (2.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2022-09-12 | |||||||
| タイトル | ||||||||
| タイトル | Sulfate activation in mitosomes plays an important role in the proliferation of entamoeba histolytica | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00067082 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Mi-ichi, Fumika
× Mi-ichi, Fumika× Makiuchi, Takashi× Furukawa, Atsushi× Sato, Daisuke× Nozaki, Tomoyoshi |
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| 著者別表示 |
古川, 敦
× 古川, 敦
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域薬学系 | |||||||
| 書誌情報 |
PLoS Neglected Tropical Diseases 巻 5, 号 8, p. e1263, 発行日 2011-08 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1935-2727 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1935-2735 | |||||||
| DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1371/journal.pntd.0001263 | |||||||
| 出版者 | ||||||||
| 出版者 | Public Library of Science | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Mitochondrion-related organelles, mitosomes and hydrogenosomes, are found in a phylogenetically broad range of organisms. Their components and functions are highly diverse. We have previously shown that mitosomes of the anaerobic/microaerophilic intestinal protozoan parasite Entamoeba histolytica have uniquely evolved and compartmentalized a sulfate activation pathway. Although this confined metabolic pathway is the major function in E. histolytica mitosomes, their physiological role remains unknown. In this study, we examined the phenotypes of the parasites in which genes involved in the mitosome functions were suppressed by gene silencing, and showed that sulfate activation in mitosomes is important for sulfolipid synthesis and cell proliferation. We also demonstrated that both Cpn60 and unusual mitochondrial ADP/ATP transporter (mitochondria carrier family, MCF) are important for the mitosome functions. Immunoelectron microscopy demonstrated that the enzymes involved in sulfate activation, Cpn60, and mitochondrial carrier family were differentially distributed within the electron dense, double membrane-bounded organelles. The importance and topology of the components in E. histolytica mitosomes reinforce the notion that they are not "rudimentary" or "residual" mitochondria, but represent a uniquely evolved crucial organelle in E. histolytica. © 2011 Mi-ichi et al. | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © 2011 Mi-ichi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||
| 権利 | ||||||||
| 権利情報 | This is an Open Access article under the CC BY license. | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0001263 | |||||||
| 関連名称 | https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0001263 | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.plosNTDS.org/ | |||||||
| 関連名称 | http://www.plosNTDS.org/ | |||||||
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| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.plos.org/ | |||||||
| 関連名称 | http://www.plos.org/ | |||||||
