| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-03 |
| タイトル |
|
|
タイトル |
脳腫瘍識別を目指した共焦点顕微鏡による腫瘍観察 |
| タイトル |
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|
タイトル |
Observation of brain tumor for the discrimination using a confocal laser scanning microscope |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00008712 |
|
ID登録タイプ |
JaLC |
| 著者 |
栂野, 浩太郎
米山, 猛
濱田, 潤一郎
林, 裕
中田, 光俊
渡辺, 哲陽
香川, 博之
|
| 著者別表示 |
Togano, Kotaro
Yoneyama, Takeshi
Hamada, Jun-ichiro
Hayashi, Yutaka
Nakada, Mitsutoshi
Watanabe, Tetsuyou
Kagawa, Hiroyuki
|
| 書誌情報 |
Transactions of Japanese Society for Medical and Biological Engineering
巻 50,
号 1,
p. 62-67,
発行日 2012-01-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1347-443X |
| NCID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11633569 |
| 出版者 |
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|
出版者 |
Japanese Society for Medical and Biological Engineering = 日本生体医工学会 JSMBE |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
During surgery to remove a brain tumor it is important to discriminate normal tissue from cancerous tissue. Here we report a method to identify tumor tissue using a confocal microscope with laser illumination. The confocal microscope has several useful qualities for this work:it has high resolution and can also reject light that is not from the focal plane. The microscope was set up with an illumination laser of wavelength 405nm and a red fluorescence filter at wavelength 610-680 nm in front of the CCD camera. This arrangement attenuated the direct light of the laser to increase the contrast in the fluorescence image. The field of view of the microscope was about 100μm square with a×40 objective. Before surgery, the patient drank a solution containing 5-ALA which induces formation of fluorescent porphyrins in tumors of type glioblastoma. Tissue samples taken during surgery were put onto the microscope stage. CCD images were obtained and it was found that tumor tissue emitted more red light and could be visually distinguished from normal tissue in the images. To quantify the difference, the intensity of all red pixels was added to form a total intensity in several images. The CCD red response to tumor tissue was found to be more than 2 times the response to normal tissue. We conclude that the confocal microscope method can distinguish tumor tissue at distance scale 100 μm. |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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|
識別子タイプ |
URI |
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|
関連識別子 |
http://ci.nii.ac.jp/naid/40019319088 |
| 関連URI |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.asas.or.jp/jsmbe/ |
TE-PR-YONEYAMA-T-62.pdf (332.7 kB)
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